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Dissociating prefrontal and hippocampal function in episodic memory encoding

机译：在发作性记忆编码中分离前额叶和海马功能

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Human lesion data indicate that an intact left hippocampal formation is necessary for auditory-verbal memory. By contrast, functional neuroimaging has highlighted the role of the left prefrontal cortex but has generally failed to reveal the predicted left hippocampal activation. Here we describe an experiment involving learning category-exemplar word pairs (such as 'dog...boxer') in which we manipulate the novelty of either individual elements or the entire category-exemplar pairing. We demonstrate both left medial temporal (including hippocampal) and left prefrontal activation and show that these activations are dissociable with respect to encoding demands. Left prefrontal activation is maximal with a change in category-exemplar pairings, whereas medial temporal activation is sensitive to the overall degree of novelty. Thus, left prefrontal cortex is sensitive to processes required to establish meaningful connections between a category and its exemplar, a process maximized when a previously formed connection is changed. Conversely, the left medial temporal activation reflects processes that register the overall novelty of the presented material. Our results provide striking evidence of functionally dissociable roles for the prefrontal cortex and hippocampal formation during learning of auditory-verbal material.
机译：人类病变数据表明完整的左海马结构对于听觉-语言记忆是必要的。相比之下，功能性神经影像学突出显示了左前额叶皮层的作用，但通常无法揭示预测的左海马激活。在这里，我们描述了一个涉及学习类别-示例词对（例如“ dog ... boxer”）的实验，在该实验中，我们操纵单个元素或整个类别-示例对的新颖性。我们证明左内侧颞叶（包括海马）和左前额叶激活，并表明这些激活是可分离的编码需求方面。左前额叶激活最大，类别-示例配对发生变化，而内侧颞叶激活对整体的新颖性敏感。因此，左前额叶皮层对在类别及其示例之间建立有意义的连接所需的过程敏感，当更改先前形成的连接时，该过程将最大化。相反地​​，左内侧颞部激活反映了记录所呈现材料整体新颖性的过程。我们的研究结果提供了惊人的证据，说明在听觉语言材料学习过程中前额叶皮层和海马结构的功能分离作用。

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