The importance of being selective

John T. Groves

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The importance of being selective

机译：选择性的重要性

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Hydroxylating enzymes introduce one or more O-H groups into organic compounds and are involved in many biological processes. But how do they work? And how might these systems be redesigned to practical ends? Bioorganic chemists address these questionsby using synthetic molecular systems. A striking example of such research appears in the Journal of the American Chemical Society, where Breslow et al. describe the catalytic hydroxylation of a steroid using an artificial cytochrome P-450 enzyme. What is remarkable about this report is both the positional selectivity the authors have achieved, and that the reaction exhibits true catalytic turnover of steroid molecules.

机译：羟化酶将一个或多个O-H基团引入有机化合物，并参与许多生物过程。但是它们如何工作？以及如何将这些系统重新设计以达到实际目的？生物有机化学家通过使用合成分子系统解决了这些问题。此类研究的一个显着例子出现在《美国化学学会杂志》上，布雷斯洛等人（Breslow等人）。美国专利No.5,775,404描述了使用人工细胞色素P-450酶催化类固醇的羟基化反应。该报告的显着之处在于作者实现了位置选择性，并且该反应展现出类固醇分子的真正催化转化。

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《Nature》 |1997年第6649期|p.329-330|共2页
作者
John T. Groves;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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4. Evaluation of detection l imit and selectivity coefficient for sinle ion-selective sensors and an array of non-selective sensors [C] . A.V.Legin A.M.Rudnitskaya, Yu.G.Vlasov, C.Di Natale, European conference on solid-state transducers;UK conference on sensors and their applications . 1998

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The importance of being selective

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