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首页> 外文期刊>Nature >A TETRODOTOXIN-RESISTANT VOLTAGE-GATED SODIUM CHANNEL EXPRESSED BY SENSORY NEURONS
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A TETRODOTOXIN-RESISTANT VOLTAGE-GATED SODIUM CHANNEL EXPRESSED BY SENSORY NEURONS

机译：感觉神经元表达的抗河豚毒素的电压门控钠离子通道

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摘要

DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated by tissue-damage, express an unusual voltage-gated sodium channel that is resistant to tetrodotoxin(1-9). We report here that we have identified a 1,957 aminoacid sodium channel in these cells that shows 65% identity with the rat cardiac tetrodotoxin-insensitive sodium channel(10), and is not expressed in other peripheral and central neurons, glia or non-neuronal tissues. In situ hybridization shows that the channel is expressed only by small-diameter sensory neurons in neonatal and adult dorsal root and trigeminal ganglia. The channel is resistant to tetrodotoxin when expressed in Xenopus oocytes. The electrophysiological and pharmacological properties of the expressed channel are similar to those described for the small-diameter sensory neuron tetrodotoxin-resistant sodium channels. As some noxious input into the spinal cord is resistant to tetrodotoxin(8,11,12), block of expression or function of such a C-fibre-restricted sodium channel may have a selective analgesic effect. [References: 30]
机译：与C纤维相关的DORSAL根神经节感觉神经元表达了异常的电压门控钠通道，该通道对河豚毒素具有抗性（1-9），其中C纤维中的许多被组织损伤激活。我们在这里报告我们已经在这些细胞中鉴定出一个1,957个氨基酸的钠通道，该通道与大鼠对河豚毒素不敏感的钠通道（10）有65％的同一性，并且在其他周围和中枢神经元，神经胶质或非神经元组织中未表达。原位杂交表明，该通道仅由新生和成年背根和三叉神经节中的小直径感觉神经元表达。当在非洲爪蟾卵母细胞中表达时，该通道对河豚毒素具有抗性。所表达的通道的电生理学和药理学性质与针对小直径感觉神经元河豚毒素抗性钠通道的描述相似。由于一些有害的脊髓输入对河豚毒素具有抗性（8,11,12），因此这种C纤维限制的钠通道的表达或功能受阻可能具有选择性的镇痛作用。 [参考：30]

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