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INHIBITION OF MONOAMINE OXIDASE B IN THE BRAINS OF SMOKERS

机译：烟熏脑中单胺氧化酶B的抑制作用

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THE massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking(1). Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders(2) and is associated with a decreased risk of Parkinson's disease(3), Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine(4), as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species 5, We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking. [References: 31]
机译：烟草烟雾的成瘾性和当前戒烟方法的有限成功加剧了与吸烟相关的大规模健康问题（1）。然而，关于卷烟烟雾的神经药理学作用却对吸烟行为知之甚少，或者为什么吸烟在精神疾病中如此普遍（2）并与帕金森氏病风险降低相关（3），在这里我们报道了人们的大脑与不吸烟者或以前的吸烟者相比，吸烟者的单胺氧化酶B（MAO B; EC 1.4.3.4）水平降低40％。 MAO B参与多巴胺的分解，多巴胺是一种神经递质，与增强和激励行为以及运动有关。因此，MAO B的抑制与多巴胺的活性增强有关（4），并且与过氧化氢的生成减少有关，而过氧化氢是一种活性氧5的来源。我们建议降低MAO B的活性可以与尼古丁协同产生多种行为。和吸烟的流行病学影响。 [参考：31]

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