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INVESTIGATION OF MONOAMINE OXIDASE INHIBITORY ACTIVITIES OF NEW CHALCONE DERIVATIVES: COMPARISON OF LC-MS/MS AND FLUOROMETRIC METHODS

机译：新硫酮衍生物单胺氧化酶抑制活性的研究：LC-MS / MS和荧光法的比较

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Monoamine oxidase (MAO), is a key enzyme that metabolizes monoamine neurotransmitters in peripheral tissues and in the central nervous system [1]. MAO involves two isoforms, i.e. MAO-A and MAO-B. MAO-A inhibitors constitute a well-known class of antidepressant drugs, whereas MAO-B inhibitors have importance towards age-related disorders such as Alzheimer's and Parkinson's diseases [2]. In the present work, we applied both fluorometric and LC-MS/MS assays to observe MAO inhibitory potency of new chalcone derivatives.

机译：单胺氧化酶（MAO），是一种关键酶，其在外周组织和中枢神经系统中代谢单胺神经递质[1]。毛涉及两种同种型，即毛A和Mao-b。毛泽东抑制剂构成着一种着名的抗抑郁药物，而MAO-B抑制剂具有与年龄相关的疾病，例如阿尔茨海默氏症和帕金森的疾病[2]。在本作的工作中，我们应用荧光和LC-MS / MS测定以观察新的硫酮衍生物的MAO抑制效力。

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《International Mass Spectrometry Conference》|2018年|p628-1245|共2页
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作者
Umide Demir Ozkay; Nafiz Oncu Can; Serkan Levent; Yusuf Ozkay; Ozgur Devrim Can;
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正文语种
中图分类分析化学;
关键词
Monoamine Oxidase; Inhibition; Chalcone; LC-MS/MS;

机译：单胺氧化酶;抑制;chalcone;lc-ms / ms;

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1. Investigation of monoamine oxidase inhibitory activities of new chalcone derivatives [J] . Nafiz ?ncü Can Cukurova Medical Journal . 2018,第2期

机译：新查尔酮衍生物的单胺氧化酶抑制活性的研究
2. Potent and Selective Monoamine Oxidase-B Inhibitory Activity: Fluoro- vs. Trifluoromethyl-4-hydroxylated Chalcone Derivatives [J] . Mathew Bijo, Mathew Githa Elizabeth, Ucar Guelberk, Chemistry & biodiversity . 2016,第8期

机译：有力和选择性的单胺氧化酶-B抑制活性：氟-vs.三氟甲基-4-羟基查尔酮衍生物
3. Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases [J] . Ziane S., Mazari M. M., Safer A. M., Russian Journal of Organic Chemistry . 2019,第7期

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4. INVESTIGATION OF MONOAMINE OXIDASE INHIBITORY ACTIVITIES OF NEW CHALCONE DERIVATIVES: COMPARISON OF LC-MS/MS AND FLUOROMETRIC METHODS [C] . Umide Demir Ozkay, Nafiz Oncu Can, Serkan Levent, International Mass Spectrometry Conference . 2018

机译：新硫酮衍生物单胺氧化酶抑制活性的研究：LC-MS / MS和荧光法的比较
5. Expression and functional characterization of monoamine oxidase from the zebrafish (Danio rerio): Comparisons with human monoamine oxidases A and B. [D] . Kacar, Betul. 2009

机译：斑马鱼（Danio rerio）单胺氧化酶的表达和功能表征：与人单胺氧化酶A和B的比较。
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INVESTIGATION OF MONOAMINE OXIDASE INHIBITORY ACTIVITIES OF NEW CHALCONE DERIVATIVES: COMPARISON OF LC-MS/MS AND FLUOROMETRIC METHODS

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