MOLECULAR CHAPERONES IN CELLULAR PROTEIN FOLDING [Review]

Hartl FU.

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MOLECULAR CHAPERONES IN CELLULAR PROTEIN FOLDING [Review]

机译：细胞蛋白折叠中的分子伴侣[综述]

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The folding of many newly synthesized proteins in the cell depends on a set of conserved proteins known as molecular chaperones. These prevent the formation of misfolded protein structures, both under normal conditions and when cells are exposed to stresses such as high temperature. Significant progress has been made in the understanding of the ATP-dependent mechanisms used by the Hsp70 and chaperonin families of molecular chaperones, which can cooperate to assist in folding new polypeptide chains. [References: 155]

机译：细胞中许多新合成蛋白质的折叠取决于一组称为分子伴侣的保守蛋白质。这些在正常条件下以及当细胞暴露于高温等压力下都可以防止错误折叠的蛋白质结构的形成。在对Hsp70和分子伴侣分子伴侣蛋白家族所使用的ATP依赖机制的理解上已取得了重大进展，它们可以协同协助折叠新的多肽链。 [参考：155]

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来源
《Nature》 |1996年第6583期|p. 571-580|共10页
作者
Hartl FU.;
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作者单位

MEM SLOAN KETTERING CANC CTR HOWARD HUGHES MED INST 1275 YORK AVE NEW YORK NY 10021 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Heat-shock proteins; Ribulose bisphosphate carboxylase; Escherichia-coli groel; Atp hydrolysis; Thermophilic archaebacterium; Binding-specificity; Central cavity; Translocation; Complex; Dnak;

机译：热休克蛋白;核糖二磷酸羧化酶;大肠埃希氏菌;Atp水解;嗜热古细菌;结合特异性;中央腔;易位;复杂;Dnak;

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专利

1. Molecular Chaperones in Cellular Protein Folding: The Birth of a Field [J] . Arthur L. Horwich Cell . 2014,第2期

机译：细胞蛋白折叠中的分子伴侣：一个领域的诞生。
2. A Review: Molecular Chaperone-mediated Folding, Unfolding and Disaggregation of Expressed Recombinant Proteins [J] . Fatima Komal, Naqvi Fatima, Younas Hooria Cell biochemistry and biophysics . 2021,第2期

机译：综述：表达重组蛋白的分子伴蛋白介导的折叠，展开和分解
3. Molecular chaperones: containers and surfaces for folding, stabilising or unfolding proteins [Review] [J] . Saibil H. Current Opinion in Structural Biology . 2000,第2期

机译：分子伴侣：折叠和稳定蛋白质的容器和表面[综述]
4. Blocking the protein folding machinery. Rational design of inhibitors of the molecular chaperone Hsp90 as new anticancer agents [C] . G. COLOMBO International School of Physics "Enrico Fermi" . 2007

机译：阻止蛋白质折叠机械。作为新抗癌剂的分子伴侣HSP90抑制剂的理性设计
5. Aggrecan synthesis and secretion: A paradigm for molecular and cellular coordination of multiglobular protein folding and intracellular trafficking. [D] . Zheng, Jing. 1998

机译：Aggrecan的合成和分泌：多球蛋白折叠和细胞内运输的分子和细胞协调的范例。
6. YidC Protein a Molecular Chaperone for LacY Protein Folding via the SecYEG Protein Machinery [O] . Lu Zhu, H. Ronald Kaback, Ross E. Dalbey 2013

机译：YidC蛋白通过SecYEG蛋白机器进行LacY蛋白折叠的分子伴侣
7. Mechanisms of the Hsp70 chaperone systemThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process. [O] . Jason C. Young 2010

机译：HSP70伴侣系统的机制是题为“加拿大生物化学协会，分子和细胞生物学52年度会议 - 蛋白质折叠：原则和疾病的”加拿大生物化学协会“发表的各种文件之一，并经历了期刊的通常同行审查过程。

MOLECULAR CHAPERONES IN CELLULAR PROTEIN FOLDING [Review]

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