ESTIMATE OF THE GENOMIC MUTATION RATE DELETERIOUS TO OVERALL FITNESS IN E-COLI

Kibota TT.; Lynch M.

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ESTIMATE OF THE GENOMIC MUTATION RATE DELETERIOUS TO OVERALL FITNESS IN E-COLI

机译：大肠杆菌总体适应性的遗传突变率估计

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MUTATIONS are a double-edged sword: they are the ultimate source of genetic variation upon which evolution depends, yet most mutations affecting fitness (viability and reproductive success) appear to be harmful(1). Deleterious mutations of small effect can escape natural selection, and should accumulate in small populations(2-4). Reduced fitness from deleterious-mutation accumulation may be important in the evolution of sex(5-7), mate choice(8,9), and diploid life-cycles(10), and in the extinction of small populations(11,12). Few empirical data exist, however. Minimum estimates of the genomic deleterious-mutation rate for viability in Drosophila melanogaster are surprisingly high(1,13,14), leading to the conjecture that the rate for total fitness could exceed 1.0 mutation per individual per generation(5,6). Here we use Escherichia coli to provide an estimate of the genomic deleterious-mutation rate for total fitness in a microbe. We estimate that the per-microbe rate of deleterious mutations is in excess of 0.0002. [References: 24]

机译：突变是一把双刃剑：它们是进化所依赖的遗传变异的最终来源，但大多数影响适应性的变异（生存力和生殖成功）似乎都是有害的（1）。效果较小的有害突变可以逃避自然选择，应在少数人群中积累（2-4）。有害突变积累导致的适应性降低可能对性别（5-7），配偶选择（8,9）和二倍体生命周期（10）的进化以及小种群的灭绝（11,12）具有重要意义。。但是，几乎没有经验数据。果蝇果蝇生存能力的基因组有害突变率的最低估计值高得令人惊讶（1,13,14），导致人们推测总适应率可能超过每代每一人1.0个突变（5,6）。在这里，我们使用大肠杆菌来估计微生物总体适应性的基因组有害突变率。我们估计每微生物有害突变率超过0.0002。 [参考：24]

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来源
《Nature》 |1996年第6584期|p. 694-696|共3页
作者
Kibota TT.; Lynch M.;
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作者单位

CLARK COLL DEPT BIOL 1800 E MCLOUGHLIN BLVD VANCOUVER WA 98663 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Populations; Evolution;

机译：人口;进化;

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专利

1. Mutation accumulation in real branches: fitness assays for genomic deleterious mutation rate and effect in large-statured plants. [J] . Schultz S. T., Scofield D. G. The American Naturalist: Devoted to the Conceptual Unification of the Biological Sciences . 2009,第2期

机译：真实分支中的突变积累：适用于大型植物的基因组有害突变率和效应的适合性测定。
2. Estimating the Fitness Effect of Deleterious Mutations During the Two Phases of the Life Cycle: A New Method Applied to the Root-Rot Fungus Heterobasidion parviporum [J] . Clergeot Pierre-Henri, Rode Nicolas O., Glemin Sylvain, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2019,第3期

机译：估算生命周期两阶段存在有害突变的健身效应：一种施用对根腐菌的新方法Paridobasidion Parviporum
3. Estimation of the rate and effects of deleterious genomic mutations in finite populations with linkage disequilibrium [J] . Li J, Deng HW Heredity: An International Journal of Genetics . 2005,第1期

机译：具有连锁不平衡的有限群体中有害基因组突变的发生率和影响的估计
4. On Fitness Distributions and Expected Fitness Gain of Mutation Rates in Parallel Evolutionary Algorithms [C] . David W. Corne, Martin J. Oates, Douglas B. Kell 7th International Conference on Parallel Problem Solving from Nature - PPSN VII, Sep 7-11, 2002, Granada, Spain . 2002

机译：并行进化算法中变异率的适应度分布和期望适应度增益
5. Fitness, developmental stability, and germline mutation rates in white -footed mice (Peromyscus leucopus) chronically exposed to heavy metal contamination [D] . Guan, Dongming 2007

机译：长期暴露于重金属污染的白脚小鼠（白带病）的适应性，发育稳定性和种系突变率
6. Estimating the Fitness Effect of Deleterious Mutations During the Two Phases of the Life Cycle: A New Method Applied to the Root-Rot Fungus Heterobasidion parviporum [O] . Pierre-Henri Clergeot, Nicolas O. Rode, Sylvain Glémin, 2019

机译：估算生命周期两个阶段中有害突变的适应性效应：一种应用于根腐菌异小孢子小孢子的新方法
7. Estimating the fitness effect of deleterious mutations during the two phases of the life cycle: a new method applied to the root-rot fungusHeterobasidion parviporum [O] . Pierre-Henri Clergeot, Nicolas O. Rode, Sylvain Glémin, 2018

机译：估算生命周期两相期间有害突变的健身效应：一种新方法应用于根腐毒性株的新方法Parviporum

ESTIMATE OF THE GENOMIC MUTATION RATE DELETERIOUS TO OVERALL FITNESS IN E-COLI

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