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IDENTIFICATION OF A MAJOR CO-RECEPTOR FOR PRIMARY ISOLATES OF HIV-1

机译:主要的HIV-1分离株共同受体的鉴定

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Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1 alpha and MIP-1 beta. [References: 44]
机译:HIV-1进入靶细胞需要细胞表面CD4和其他宿主细胞辅助因子。最近发现了一种病毒感染所需的辅因子,该病毒适合于在转化的T细胞系中生长。然而,融合蛋白不促进巨噬细胞嗜性病毒的进入,其被认为是体内关键的致病菌株。由HIV-1原代巨噬细胞嗜性株的包膜糖蛋白介导的进入的主要辅因子是CC-CKR-5,它是β-趋化因子RANTES,MIP-1α和MIP-1β的受体。 [参考:44]

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