CLONAL SELECTION AND LEARNING IN THE ANTIBODY SYSTEM [Review]

Rajewsky K.

首页> 外文期刊>Nature >CLONAL SELECTION AND LEARNING IN THE ANTIBODY SYSTEM [Review]

【24h】

CLONAL SELECTION AND LEARNING IN THE ANTIBODY SYSTEM [Review]

机译：抗体系统中的克隆选择和学习[综述]

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation. Here only mutants binding antigen with high affinity survive to become memory cells. Cells expressing autoreactive receptors are counter-selected at both stages. This stringent positive and negative selection allows the generation and diversification of cells while rigorously controlling their specificity. [References: 182]

机译：每个产生抗体的B细胞都产生独特的特异性抗体，反映出一系列有序的基因重排，如果细胞要存活，则必须成功进行。在免疫反应期间发生第二选择过程，其中通过体细胞超突变产生新的抗体库。在此，只有具有高亲和力的结合抗原的突变体才能存活成为记忆细胞。在两个阶段均会反选表达自身反应性受体的细胞。这种严格的阳性和阴性选择可以在严格控制细胞特异性的同时，使细胞生成和多样化。 [参考：182]

著录项

来源
《Nature》 |1996年第6585期|p. 751-758|共8页
作者
Rajewsky K.;
展开▼
作者单位

UNIV COLOGNE INST GENET WEYERTAL 121 D-50931 COLOGNE GERMANY;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Pre-b-cells; Chain gene rearrangement; Reactive lymphocytes-b; Immunoglobulin heavy-chains; D-mu protein; Immune-response; Germinal-centers; Bone-marrow; Somatic hypermutation; Transgenic mice;

机译：前b细胞;链基因重排;反应性淋巴细胞b;免疫球蛋白重链;D-mu蛋白;免疫反应;女性中心;骨髓;体细胞高突变;转基因小鼠;

相似文献

外文文献
中文文献
专利

1. Rapid automated selection of mammalian cell line secreting high level of humanized monoclonal antibody using Clone Pix FL system and the correlation between exterior median intensity and antibody productivity [J] . Dharshanan Suba, Chong Heilly, Swee Hung Cheah, Electronic Journal of Biotechnology . 2011,第2期

机译：使用Clone Pix FL系统快速自动选择分泌高水平人源化单克隆抗体的哺乳动物细胞系，以及外部中值强度与抗体生产率之间的相关性
2. Nature and Clonality of the Fluoresceinated Secondary Antibody in Luminex Multiplex Bead Assays Are Critical Factors for Reliable Monitoring of Serum HLA Antibody Levels in Patients for Donor Organ Selection, Desensitization Therapy, and Assessment of the Risk for Graft Loss [J] . Ravindranath Mepur H., Jucaud Vadim, Banuelos Nubia, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2017,第11期

机译：Luminex多重珠子测定中荧光次级抗体的性质和克隆性是用于患者患者患者血清HLA抗体水平的血清HLA抗体水平的关键因素，以及评估移植损失的风险
3. Nature and Clonality of the Fluoresceinated Secondary Antibody in Luminex Multiplex Bead Assays Are Critical Factors for Reliable Monitoring of Serum HLA Antibody Levels in Patients for Donor Organ Selection, Desensitization Therapy, and Assessment of the Risk for Graft Loss [J] . Mepur H. Ravindranath, Vadim Jucaud, Nubia Banuelos, The journal of immunology . 2017,第11期

机译：Luminex多重珠试验中荧光素化二抗的性质和克隆性是可靠监测供体器官选择，脱敏治疗和评估移植物丢失风险的患者血清HLA抗体水平的关键因素
4. Towards improved Clonal Selection Algorithm by increasing the diversity degree of antibody [C] . Xu Xiaowen, Chen Weibin 2011 6th IEEE Joint International Information Technology and Artificial Intelligence Conference . 2011

机译：通过提高抗体的多样性来改进克隆选择算法
5. A systematic evaluation of search methods, search reporting, and selection methods of reviews of physical activity interventions to prevent obesity. [D] . Anderson, Margaret J. 2009

机译：对预防肥胖的身体活动干预措施的搜索方法，搜索报告和选择评论的方法进行系统评估。
6. PNAS Plus: Antibody selection using clonal cocultivation of Escherichia coli and eukaryotic cells in miniecosystems [O] . Tianqing Zheng, Jia Xie, Zhuo Yang, 2018

机译：PNAS Plus：在小型生态系统中使用大肠杆菌和真核细胞的克隆共培养进行抗体选择
7. Modified Clonal Selection Algorithm for Learning Qualitative Compartmental Models of Metabolic Systems [O] . Wei Pang, George M. Coghill 2014

机译：用于学习代谢系统定性格模型的改进的克隆选择算法

CLONAL SELECTION AND LEARNING IN THE ANTIBODY SYSTEM [Review]

摘要

著录项

相似文献

相关主题

期刊订阅