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Feeding inhibition by neuropeptide Y

机译：神经肽Y的进食抑制

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Sir — OB protein (leptin) is a circulating signal linking fat mass to the brain control of energy balance. Administration of OB protein to the brain induces long-last-ing reductions in food intake and body weight of obese ob/ob mice. This striking finding, together with the observation that the circulating OB protein concentration is proportional to body fat in humans, has stimulated research on the brain mechanisms involved in OB protein action. The inhibitory effects of OB protein on neuropeptide Y gene expression and secretion have led to the proposal that neuropeptide Y, a potent stimulator of feeding, is the major mediator of the actions of OB protein. To test this hypothesis, we examined the interaction of brain administration of OB protein and neuropeptide Y on the feeding behaviour of ob/ob mice. We found that OB protein inhibits the expected feeding following administration of neuropeptide Y. This result indicates that OB protein can functionally antagonize the actions of exogenous neuropeptide Y and suggests that the receptor-mediated actions of this neuropeptide on feeding are under the control of OB protein.
机译：先生-OB蛋白（瘦素）是一种循环信号，将脂肪与大脑的能量平衡控制联系在一起。将OB蛋白施用到大脑会导致肥胖的ob / ob小鼠的食物摄入量和体重长期持续减少。这一惊人发现以及人们对循环中的OB蛋白浓度与人体脂肪成正比的观察结果，刺激了对涉及OB蛋白作用的大脑机制的研究。 OB蛋白对神经肽Y基因表达和分泌的抑制作用导致了这样的提议，即神经肽Y是一种有效的进食刺激剂，是OB蛋白作用的主要介质。为了验证这一假设，我们研究了大脑施用OB蛋白和神经肽Y对ob / ob小鼠摄食行为的相互作用。我们发现OB蛋白在施用神经肽Y后抑制了预期的进食。该结果表明OB蛋白可以在功能上拮抗外源性神经肽Y的作用，并表明该神经肽对进食的受体介导作用受OB蛋白的控制。

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