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首页> 外文期刊>Nature >CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.
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CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.

机译：CD8增强了稳定的T细胞受体/ MHC I类分子复合物的形成。

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摘要

T-cell antigen receptors (TCR) generally interact with moderate affinity with the complex formed by major histocompatibility complex (MHC) molecules and foreign peptides. MHC/TCR recognition is followed by the generation of a signal to the T cell through a monomorphic multicomponent system that includes the CD3 complex and accessory molecules such as CD4 and CD8. The interaction between the extracellular domains of MHC and TCR molecules, and the interaction of MHC and CD4/CD8 molecules, have been considered to occur independently of one another. We report here that the affinity of CD8 dimers for MHC class I molecules is independent of haplotype and peptide content, and that the affinity of the TCR for its specific ligand is enhanced through a reduced 'off' rate in the presence of either CD8alpha alpha homo- or CD8alpha beta heterodimers. Moreover, CD8 seems to help recognition of the specific MHC-peptide complex either by guiding an energetically favourable docking of TCR onto MHC, or by inducing conformational changes in the MHC complex that can augment the TCR/MHC-peptide interaction. CD8 should therefore be considered as an active participant in the T-cell recognition complex, rather than simply as an accessory molecule.
机译：T细胞抗原受体（TCR）通常与主要组织相容性复合物（MHC）分子和外源肽形成的复合物以中等亲和力相互作用。在MHC / TCR识别之后，通过单态多组分系统向T细胞产生信号，该系统包括CD3复合物和辅助分子（例如CD4和CD8）。 MHC和TCR分子的胞外域之间的相互作用以及MHC和CD4 / CD8分子的相互作用被认为是相互独立发生的。我们在这里报告，CD8二聚体对MHC I类分子的亲和力与单倍型和肽含量无关，并且在任一CD8alpha alpha均存在的情况下，通过降低的“关闭”率，TCR对其特异性配体的亲和力得以增强-或CD8alpha beta异二聚体。此外，CD8似乎可以通过引导TCR在能量上有利的对接到MHC上，或通过在MHC复合物中诱导构象变化来增强TCR / MHC-肽相互作用来帮助识别特定的MHC-肽复合物。因此，CD8应该被视为T细胞识别复合体的积极参与者，而不是简单地作为辅助分子。

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