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首页> 外文期刊>Nature >Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF.
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Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF.

机译：发育中的运动神经元通过GDNF从程序性和轴切术诱导的细胞死亡中救出。

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摘要

During normal development of the vertebrate nervous system, large numbers of neurons in the central and peripheral nervous system undergo naturally occurring cell death. For example, about half of all spinal motor neurons die over a period of a few days in developing avian, rat and mouse embryos. Previous studies have shown that extracts from muscle and brain, secreted factors from glia, as well as several growth factors and neurotrophic agents, including muscle-derived factors, can promote the survival of developing motor neurons in vitro and in vivo. But because neurotrophins and other known trophic agents administered alone or in combination are insufficient to rescue all developing motor neurons from cell death, other neurotrophic molecules are probably essential for the survival and differentiation of motor neurons. Here we report that glial-cell-line-derived neurotrophic factor (GDNF), a potent neurotrophic factor that enhances survival of mammalian midbrain dopaminergic neurons, rescues developing avian motor neurons from natural programmed cell death in vivo and promotes the survival of enriched populations of cultured motor neurons. Furthermore, treatment with this agent in vivo also prevents the induced death and atrophy of both avian and mouse spinal motor neurons following peripheral axotomy.
机译：在脊椎动物神经系统的正常发育过程中，中枢和外周神经系统中的大量神经元经历自然发生的细胞死亡。例如，在发育中的禽类，大鼠和小鼠胚胎中，约有一半的脊髓运动神经元在几天内死亡。先前的研究表明，肌肉和大脑的提取物，神经胶质的分泌因子以及几种生长因子和神经营养剂（包括肌肉衍生的因子）可以促进发育中的运动神经元在体外和体内的存活。但是，由于单独或组合施用的神经营养蛋白和其他已知营养剂不足以挽救所有发育中的运动神经元免于细胞死亡，因此其他神经营养分子可能对于运动神经元的存活和分化至关重要。在这里我们报告神经胶质细胞系神经营养因子（GDNF），一种有效的神经营养因子，可增强哺乳动物中脑多巴胺能神经元的存活，从体内自然程序性细胞死亡中拯救发育中的鸟类运动神经元，并促进了丰富的人类神经营养因子的存活。培养的运动神经元。此外，在体内用该试剂进行治疗还可以防止外周轴索切开术后禽类和小鼠脊髓运动神经元的死亡和萎缩。

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