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首页> 外文期刊>Nature >Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.
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Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.

机译：胸腺皮质诱导的发育控制点，由胸腺细胞亚群调节。

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摘要

T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the thymic stromal cells with TCR-positive thymocytes are necessary for the development of the thymic medulla. Comparable requirements for the differentiation of the cortex have not been defined, however. Here we analyse mutant mouse strains to assess the function of early prothymocytes in the induction of the thymic cortex. We find that animals with a developmental block at the earliest stage of T-lineage commitment lack a functional thymic cortex. This abnormality could be corrected in fetal but not adult animals by transplantation of either fetal or adult wild-type haematopoietic stem cells. Thus a developmentally restricted interaction of fetal stromal cells with early prothymocytes is required for the induction of a cortical microenvironment. In addition, a normal thymic architecture is necessary for sustained T-cell ontogeny.
机译：α/βT细胞受体（TCR）谱系的T淋巴细胞在胸腺中成熟，在那里经历一系列分化，扩增和选择过程。为了使正常的T细胞发生，胸腺细胞必须与皮质和髓样胸腺基质细胞发生物理相互作用。同时，胸腺基质细胞与TCR阳性胸腺细胞的相互作用对于胸腺髓质的发育是必需的。但是，对于皮层分化的可比较要求尚未定义。在这里，我们分析突变小鼠品系，以评估早期胸腺细胞在胸腺皮质诱导中的功能。我们发现在T谱系承诺的最早阶段具有发育障碍的动物缺乏功能性胸腺皮质。通过胎儿或成年野生型造血干细胞的移植，这种异常可以在胎儿而非成年动物中得到纠正。因此，诱导胚胎皮层微环境需要胎儿基质细胞与早期胸腺细胞的发育受限的相互作用。另外，正常的胸腺结构对于持续的T细胞个体发育是必需的。

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