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首页> 外文期刊>Nature >A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor.
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A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor.

机译：视网膜母细胞瘤蛋白在增强糖皮质激素受体转录激活中的作用。

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摘要

The Saccharomyces cerevisiae SNF2/SWI2 protein is essential for the regulated expression of a variety of genes. A human SWI2/SNF2 homologue, hBrm, is a positive participant in glucocorticoid-receptor-mediated transcription, but its mechanism of action is not known. The retinoblastoma protein, RB, has also been shown to stimulate the transcription of several genes, although the target for RB has not been identified in any of these transcriptional events. Here we show that RB upregulates glucocorticoid-receptor-mediated transcription. The effect of either RB or hBrm is dependent on the presence of the other. Furthermore, we demonstrate that RB and hBrm interact with one another in vitro and in vivo. These results highlight a new role for RB, which is to interact with hBrm in order to potentiate glucocorticoid-receptor-activated transcription.
机译：酿酒酵母SNF2 / SWI2蛋白对于调节各种基因的表达至关重要。人类SWI2 / SNF2同源物hBrm是糖皮质激素受体介导的转录的积极参与者，但其作用机理尚不清楚。视网膜母细胞瘤蛋白RB也已显示出能刺激多个基因的转录，尽管在任何这些转录事件中均未确定RB的靶标。在这里，我们显示RB上调糖皮质激素受体介导的转录。 RB或hBrm的作用取决于另一个的存在。此外，我们证明了RB和hBrm在体外和体内彼此相互作用。这些结果凸显了RB的新作用，即与hBrm相互作用以增强糖皮质激素受体激活的转录。

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