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首页> 外文期刊>Nature >The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing.
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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing.

机译：由树突状细胞和胸腺上皮细胞表达的DEC-205受体参与抗原加工。

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摘要

Dendritic cells and thymic epithelial cells perform important immunoregulatory functions by presenting antigens in the form of peptides bound to cell-surface major histocompatibility complex (MHC) molecules to T cells. Whereas B cells are known to present specific antigens efficiently through their surface immunoglobins, a comparable mechanism for the capture and efficient presentation of diverse antigens by dendritic cells and thymic epithelial cells has not previously been described. We show here that their antigen-presentation function is associated with the high-level expression of DEC-205, an integral membrane protein homologous to the macrophage mannose receptor and related receptors which are able to bind carbohydrates and mediate endocytosis. DEC-205 is rapidly taken up by means of coated pits and vesicles, and is delivered to a multivesicular endosomal compartment that resembles the MHC class II-containing vesicles implicated in antigen presentation. Rabbit antibodies that bind DEC-205 are presented to reactive T-cell hybridomas 100-fold more efficiently than rabbit antibodies that do not bind DEC-205. Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.
机译：树突状细胞和胸腺上皮细胞通过将抗原呈递与细胞表面主要组织相容性复合体（MHC）分子结合的肽形式呈递给T细胞，从而发挥重要的免疫调节功能。尽管已知B细胞通过其表面免疫球蛋白有效地呈递特定抗原，但是以前没有描述过类似的机制用于树突状细胞和胸腺上皮细胞捕获和有效呈递多种抗原。我们在这里显示，它们的抗原呈递功能与DEC-205的高水平表达有关，DEC-205是一种与巨噬细胞甘露糖受体和相关受体（能够结合碳水化合物并介导内吞作用）同源的完整膜蛋白。 DEC-205通过包被的凹坑和囊泡被迅速吸收，并被递送到一个多囊泡的内体隔室，该隔室类似于涉及抗原呈递的含MHC II类囊泡。与不结合DEC-205的兔子抗体相比，结合DEC-205的兔子抗体对反应性T细胞杂交瘤的反应效率高100倍。因此，DEC-205是一种新型的内吞受体，可被树突状细胞和胸腺上皮细胞用来将捕获的抗原从细胞外空间引导至专门的抗原加工区室。

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