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首页> 外文期刊>Nature >Sensory but not motor neuron deficits in mice lacking NT4 and BDNF.
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Sensory but not motor neuron deficits in mice lacking NT4 and BDNF.

机译：缺乏NT4和BDNF的小鼠感觉神经元但运动神经元不足。

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摘要

Neurotrophins play important roles in neuronal survival during vertebrate development. Neurotrophin-4 (NT4), alone or in combination with brain-derived neurotrophic factor (BDNF), has been suggested to be necessary for the survival of peripheral sensory neurons and central nervous system (CNS) neurons, including motor neurons. To define the role of NT4 in vivo, we generated mice lacking NT4 by gene targeting. NT4-deficient mice were viable but exhibited a loss of sensory neurons in the nodose-petrosal and geniculate ganglia. In contrast, motor neurons of the facial nucleus and sympathetic neurons of the superior cervical ganglion were unaffected, and there was no obvious loss of dopaminergic neurons in the substantia nigra. In mice lacking both NT4 and BDNF, facial neurons remained unaffected, whereas the loss of sensory neurons was more severe than with either mutation alone. Thus NT4 is required during development for the survival of some peripheral sensory neurons but not sympathetic or motor neurons.
机译：神经营养蛋白在脊椎动物发育过程中在神经元存活中起重要作用。已经建议单独或与脑源性神经营养因子（BDNF）组合使用Neurotrophin-4（NT4）对于周围感觉神经元和中枢神经系统（CNS）神经元（包括运动神经元）的生存是必需的。为了定义NT4在体内的作用，我们通过基因靶向产生了缺乏NT4的小鼠。 NT4缺陷的小鼠是可行的，但在结节型和膝状神经节中表现出感觉神经元缺失。相反，面部核的运动神经元和上颈神经节的交感神经元未受影响，黑质中没有明显的多巴胺能神经元丢失。在既缺乏NT4又缺乏BDNF的小鼠中，面部神经元仍然不受影响，而感觉神经元的丧失比任何一种突变都更为严重。因此，在发育过程中，NT4是某些周围感觉神经元但不是交感神经元或运动神经元生存所必需的。

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