Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

Walter MR; Windsor WT; Nagabhushan TL; Lundell DJ; Lunn CA; Zauodny PJ; Narula SK

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

机译：干扰素-γ及其可溶性高亲和力受体之间复合物的晶体结构。

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The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

机译：与其高亲和力细胞表面受体的细胞外片段结合的干扰素-γ的晶体结构揭示了第2类细胞因子受体-配体复合物的第一个视图。在复合物中，一个干扰素-γ同型二聚体结合两个受体分子。与第1类生长激素受体复合物不同，这两种干扰素-γ受体彼此不相互作用，被27 A隔开。受体结合后，干扰素-γ的柔性AB环发生构象变化，其中包括3（10）螺旋。

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来源
《Nature》 |1995年第6537期|P.230-235|共6页
作者
Walter MR; Windsor WT; Nagabhushan TL; Lundell DJ; Lunn CA; Zauodny PJ; Narula SK;
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作者单位

Department of Pharmacology, University of Alabama at Birmingham 35294, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Interferon Type II; Receptors; Interferon; Cytokines; Receptors; Somatotropin; 干扰素Ⅱ型; 受体; 干扰素;

机译：Interferon Type II;Receptors;Interferon;Cytokines;Receptors;Somatotropin;干扰素Ⅱ型;受体;干扰素;

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

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