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首页> 外文期刊>Nature >Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes.
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Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes.

机译：扁桃体星形胶质细胞中anandamide对间隙连接和细胞间钙信号的抑制作用。

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摘要

Anandamide, an endogenous arachidonic acid derivative that is released from neurons and activates cannabinoid receptors, may act as a transcellular cannabimimetic messenger in the central nervous system. The biological actions of anandamide and the identity of its target cells are, however, still poorly documented. Here we show that anandamide is a potent inhibitor of gap-junction conductance and dye permeability in striatal astrocytes. This inhibitory effect is specific for anandamide as compared to co-released congeners or structural analogues, is sensitive to pertussis toxin and to protein-alkylating agents, and is neither mimicked by cannabinoid-receptor agonists nor prevented by a cannabinoid-receptor antagonist. Glutamate released from neurons evokes calcium waves in astrocytes that propagate via gap junctions, and may, in turn, activate neurons distant from their initiation sites in astrocytes. We find that anandamide blocks the propagation of astrocyte calcium waves generated by either mechanical stimulation or local glutamate application. Thus, by regulating gap-junction permeability, anandamide may control intercellular communication in astrocytes and therefore neuron-glial interactions.
机译：Anandamide是一种从神经元释放并激活大麻素受体的内源性花生四烯酸衍生物，可以在中枢神经系统中充当跨细胞大麻素的使者。然而，仍未充分记录Anandamide的生物学作用及其靶细胞的身份。在这里，我们显示anandamide是纹状体星形胶质细胞中间隙连接电导和染料渗透性的有效抑制剂。与共同释放的同类物或结构类似物相比，这种抑制作用对anandamide具有特异性，对百日咳毒素和蛋白质烷基化剂敏感，既不受大麻素受体激动剂的模仿，也不受大麻素受体拮抗剂的阻止。从神经元释放的谷氨酸盐会在星形胶质细胞中引起通过间隙连接传播的钙波，并进而激活远离星形胶质细胞起始位置的神经元。我们发现，anandamide阻止通过机械刺激或局部谷氨酸应用产生的星形胶质细胞钙波的传播。因此，通过调节间隙连接的通透性，阿南酰胺可以控制星形胶质细胞的细胞间通讯，从而控制神经元-神经胶质的相互作用。

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