Cytokine receptor signalling.

Ihle JN

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Cytokine receptor signalling.

机译：细胞因子受体信号转导。

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摘要

Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. Among these are the signal transducers and activators of transcription (STATs), a family of transcription factors that contribute to the diversity of cytokine responses.

机译：许多细胞功能受细胞因子受体超家族成员的调节。这些受体发出的信号取决于它们与Janus激酶（JAKs）的关联，Janus激酶将配体结合到募集到受体复合物的信号蛋白的酪氨酸磷酸化上。其中包括信号转导子和转录激活子（STATs），这是一种转录因子家族，有助于细胞因子应答的多样性。

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来源
《Nature》 |1995年第6550期|P.591-594|共4页
作者
Ihle JN;
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作者单位

Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Receptors; Cytokine; Signal Transduction; Trans-Activators; Protein-Tyrosine Kinase; 受体; 细胞活素; 信号传递;

机译：Receptors;Cytokine;Signal Transduction;Trans-Activators;Protein-Tyrosine Kinase;受体;细胞活素;信号传递;

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专利

1. Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling. [J] . Cindrova Davies T, Sanders DA, Burton GJ, Cardiovascular Research . 2011,第3期

机译：可溶性FLT1通过拮抗VEGF受体介导的信号转导使内皮细胞对炎性细胞因子敏感。
2. Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. [J] . Lejeune D, Demoulin JB, Renauld JC The Biochemical Journal . 2001,第Pta1期

机译：白介素9诱导三种细胞因子信号抑制剂的表达：细胞因子诱导的含SH2的蛋白，细胞因子信号传导（SOCS）-2和SOCS-3的抑制剂，但只有SOCS-3过表达抑制白细胞介素9的信号传导。
3. Toll-like receptors and NOD-like receptors: domain architecture and cellular signalling. [J] . Langefeld T, Mohamed W, Ghai R Advances in Experimental Medicine and Biology . 2009,第Null期

机译：Toll样受体和NOD样受体：结构域结构和细胞信号传导。
4. The interleukin-1 family cytokines and receptors in autoimmune and autoinflammatory diseases [C] . Lucchesi D., Anzilotti C., Del Corso I., European Congress of Immunology . 2009

机译：自身免疫和自身炎症疾病中白细胞介素-1家族细胞因子和受体
5. The Divergent Role of Co-Receptors and Cytokines in the Immune Response to Cancer and Self [D] . Tucker, Christopher G. 2020

机译：共同受体和细胞因子在对癌症和自我的免疫反应中的发散作用
6. Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein suppressor of cytokine signalling (SOCS)-2 and SOCS-3 but only SOCS-3 overexpression suppresses interleukin 9 signalling. [O] . D Lejeune, J B Demoulin, J C Renauld 2001

机译：白介素9诱导三种细胞因子信号抑制剂的表达：细胞因子诱导的含SH2的蛋白细胞因子信号的抑制因子（SOCS）-2和SOCS-3但只有SOCS-3过表达抑制白细胞介素9的信号传导。
7. Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling. [O] . Lejeune D, Demoulin J B, Renauld J C 2001

机译：白介素9诱导三种细胞因子信号抑制剂的表达：细胞因子诱导的含SH2的蛋白，细胞因子信号的抑制因子（SOCS）-2和SOCS-3，但只有SOCS-3过表达抑制白细胞介素9的信号传导。

Cytokine receptor signalling.

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