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首页> 外文期刊>Nature >Asymmetric segregation of Numb and Prospero during cell division.
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Asymmetric segregation of Numb and Prospero during cell division.

机译：Numb和Prospero在细胞分裂过程中的不对称分离。

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摘要

A cell can divide asymmetrically by specifically segregating a determinant into one of its daughter cells. The Numb protein is a candidate for such a determinant in the asymmetric cell divisions of the developing Drosophila nervous system. Numb is a membrane-associated protein that localizes asymmetrically during cell division and segregates into one daughter cell, where it is required for the specification of the correct cell fate. Here we show that a nuclear protein, Prospero, translocates to the membrane at the beginning of cell division and colocalizes with Numb throughout mitosis, suggesting a common mechanism for asymmetric segregation. Numb and Prospero localization is coupled to mitosis and tightly correlated with the position of one of the two centrosomes. In contrast to centrosome positioning, however, Numb and Prospero localization is independent of microtubules. Cytochalasin D treatment suggests that the process is also independent of actin. We propose that there is an organizer of asymmetric cell division which provides positional information for both the orientation of the mitotic spindle and asymmetric localization of Numb and Prospero.
机译：一个细胞可以通过将行列式特异地分离到其子细胞之一中而进行不对称分裂。 Numb蛋白是正在发展的果蝇神经系统不对称细胞分裂中这种决定簇的候选者。 Numb是一种与膜相关的蛋白质，在细胞分裂过程中不对称地定位，并分离成一个子细胞，这是规范正确细胞命运所必需的。在这里，我们显示核蛋白Prospero在细胞分裂开始时易位至膜，并在整个有丝分裂期间与Numb共定位，提示了不对称分离的常见机制。 Numb和Prospero的定位与有丝分裂有关，并且与两个中心体之一的位置紧密相关。与中心体定位相反，Numb和Prospero定位与微管无关。细胞松弛素D处理表明该过程也独立于肌动蛋白。我们建议有一个不对称细胞分裂的组织者，它为有丝分裂纺锤体的方向以及Numb和Prospero的不对称定位提供位置信息。

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