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NT-4-MEDIATED RESCUE OF LATERAL GENICULATE NEURONS FROM EFFECTS OF MONOCULAR DEPRIVATION

机译：NT-4介导的单侧神经元剥夺对侧耳神经元神经元的拯救

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ALTERING the balance of activity between the two eyes during the critical period for visual-system development profoundly affects competitive interactions among neurons in the lateral geniculate nucleus and primary visual cortex(1-6). Neurons in the lateral geniculate nucleus that are deprived of activity by closing or silencing one eye atrophy as a result of competition with non-deprived neurons for some critical factor(s) presumed to be present in the cortex. Based on their actions in the developing visual system(7-12) neurotrophins are attractive candidates for such factors. We tested whether neurotrophins mediate intracortical competition of afferents from the lateral geniculate nucleus by using monocular deprivation and a new method for highly localized, in vivo delivery of neurotrophins. This method allowed unambiguous identification of neurons that were exposed to neurotrophin. Here we report that only one neurotrophin, the TrkB ligand NT-4, rescued neurons in the lateral geniculate nucleus from the dystrophic effects of monocular deprivation. [References: 29]
机译：在视觉系统发展的关键时期，改变两只眼睛的活动平衡会深刻影响外侧膝状核和初级视觉皮层神经元之间的竞争性相互作用（1-6）。外侧膝状核中的神经元由于与未剥夺的神经元竞争某些假定的关键因子而与非剥夺的神经元竞争而关闭或沉默一只眼睛的萎缩而丧失活动能力。基于它们在视觉系统发展中的作用（7-12），神经营养蛋白是此类因素的诱人候选物。我们测试了神经营养蛋白是否通过使用单眼剥夺和高度局部化，体内传递神经营养蛋白的新方法来介导外侧膝状核的传入皮质内竞争。这种方法可以明确鉴定暴露于神经营养蛋白的神经元。在这里我们报告只有一种神经营养蛋白，TrkB配体NT-4，从单眼剥夺的营养不良影响中拯救了外侧膝状核中的神经元。 [参考：29]

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