A STRUCTURAL ROLE FOR HORMONE IN THE THYROID HORMONE RECEPTOR

Wagner RL; Apriletti JW; Mcgrath ME; West BL; Baxter JD; Fletterick

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A STRUCTURAL ROLE FOR HORMONE IN THE THYROID HORMONE RECEPTOR

机译：甲状腺激素受体中激素的结构作用

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The crystal structure of the rat a, thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphipathic helix, with its hydrophobic face constituting part of the hormone binding cavity. These observations suggest a structural role for ligand, in establishing the active conformation of the receptor, that is likely to underlie hormonal regulation of gene expression for the nuclear receptors.

机译：与甲状腺激素激动剂结合的大鼠α，甲状腺激素受体配体结合结构域的晶体结构表明，配体作为疏水核心的一部分完全埋在该结构域内。另外，羧基末端活化域形成两亲性螺旋，其疏水性表面构成激素结合腔的一部分。这些观察结果表明配体在建立受体的活性构象中的结构作用，这可能是核受体基因表达的激素调节的基础。

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来源
《Nature》 |1995年第6558期|p.690-697|共8页
作者
Wagner RL; Apriletti JW; Mcgrath ME; West BL; Baxter JD; Fletterick;
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作者单位

Wagner RL, UNIV CALIF SAN FRANCISCO, GRAD GRP BIOPHYS, SAN FRANCISCO, CA 94143, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
V erba; Estrogen receptor; Nuclear receptor; Dna binding; C erba; Superfamily; Refinement; Activation; Model;

机译：Verba;雌激素受体;核受体;Dna结合;Cerba;超家族;精制;活化;模型;

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1. Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor βgene promoter in response to thyroid hormone in Xenopus tadpoles in vivo [J] . Salvatore Ulisse, Graeme Esslemont, Betty S. Baker Proceedings of the National Academy of Sciences of the United States of America . 1996,第3期

机译：显性阴性突变甲状腺激素受体在体内对非洲爪蟾甲状腺激素的反应可阻止非洲爪蟾甲状腺激素受体β基因启动子的转录
2. An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone [J] . Anna T Alberobello, Valentina Congedo, Hong Liu, Journal of Translational Medicine . 2011,第1期

机译：甲状腺激素垂体选择性抵抗指数病例中，甲状腺激素受体β基因中的内含子单核苷酸多态性与垂体细胞特异性过表达的突变甲状腺激素受体β2（R338W）相关
3. The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. [J] . Latif R, Morshed SA, Zaidi M, Endocrinology and Metabolism Clinics of North America . 2009,第2期

机译：促甲状腺激素受体：促甲状腺激素和促甲状腺激素受体抗体对多聚化，切割和信号传导的影响。
4. Structural Study of Thyroid Hormone Receptor Complexes using Chemical Crosslinking - Mass Spectrometry [C] . Adriana Pianaro, Tabata R. Doratioto, Juliana Fattori, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：化学交联质谱法的甲状腺激素受体复合物的结构研究
5. Non-genomic effects of thyroid hormone receptor and thyroid hormone. [D] . Saelim, Nuttawut. 2003

机译：甲状腺激素受体和甲状腺激素的非基因组效应。
6. Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo. [O] . S Ulisse, G Esslemont, B S Baker, 1996

机译：显性阴性突变体甲状腺激素受体可阻止非洲爪蟾体内pole体内对甲状腺激素的响应从而阻止爪蟾甲状腺激素受体β基因启动子的转录。
7. Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo [O] . S. ULISSE, ESSLEMONT G, BAKER BS, 1996

机译：显性阴性突变体甲状腺激素受体在体内对非洲爪蟾甲状腺中的甲状腺激素的反应阻止了非洲爪蟾甲状腺激素受体β基因启动子的转录

A STRUCTURAL ROLE FOR HORMONE IN THE THYROID HORMONE RECEPTOR

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