Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas(aEuro)

Pollack Ian F.; Jakacki Regina I.; Butterfield Lisa H.; Hamilton Ronald L.; Panigrahy Ashok; Normolle Daniel P.; Connelly Angela K.; Dibridge Sharon; Mason Gary; Whiteside Theresa L.; Okada Hideho

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Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas(aEuro)

机译：儿科复发性低度神经胶质瘤的初步研究中，用神经胶质瘤相关抗原肽和poly-ICLC疫苗接种后的免疫应答和结果

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Low-grade gliomas (LGGs) are the most common brain tumors of childhood. Although surgical resection is curative for well-circumscribed superficial lesions, tumors that are infiltrative or arise from deep structures are therapeutically challenging, and new treatment approaches are needed. Having identified a panel of glioma-associated antigens (GAAs) overexpressed in these tumors, we initiated a pilot trial of vaccinations with peptides for GAA epitopes in human leukocyte antigen-A2+ children with recurrent LGG that had progressed after at least 2 prior regimens.

机译：低度神经胶质瘤（LGG）是儿童期最常见的脑肿瘤。尽管手术切除对于良好界定的浅表病变是治愈性的，但浸润性或深部结构引起的肿瘤在治疗上具有挑战性，并且需要新的治疗方法。在确定了在这些肿瘤中过表达的一组神经胶质瘤相关抗原（GAA）后，我们启动了在至少有2种先前方案治疗后复发的LGG的人类白细胞抗原A2 +儿童中用针对GAA表位的肽进行疫苗接种的先导试验。

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来源
《Neuro-Oncology》 |2016年第8期|1157-1168|共12页
作者
Pollack Ian F.; Jakacki Regina I.; Butterfield Lisa H.; Hamilton Ronald L.; Panigrahy Ashok; Normolle Daniel P.; Connelly Angela K.; Dibridge Sharon; Mason Gary; Whiteside Theresa L.; Okada Hideho;
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作者单位

Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Med, Pittsburgh, PA USA|Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA|Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA;

Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA|Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA;

Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA|Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA|Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA;

Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA USA|Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA|Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA|Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA;

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正文语种 eng
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关键词
astrocytoma; glioma; immunotherapy; pediatric brain tumor; vaccine therapy;

机译：星形细胞瘤;神经胶质瘤;免疫治疗;小儿脑肿瘤;疫苗治疗;

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1. Immune responses and clinical outcome after glioma-associated antigen vaccination in children with recurrent low-grade gliomas [J] . Pollack Ian F., Jakacki Regina, Butterfield Lisa, Journal of neurosurgery. . 2016,第4期

机译：复发性低度胶质瘤儿童的神经胶质瘤相关抗原疫苗接种后的免疫反应和临床结局
2. Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study [J] . Pollack Ian F., Jakacki Regina I., Butterfield Lisa H., Journal of neuro-oncology. . 2016,第3期

机译：复发性高级别神经胶质瘤患儿接种神经胶质瘤相关抗原肽后的抗原特异性免疫反应性和临床结局：一项初步研究的结果
3. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas [J] . PollackI.F., JakackiR.I., ButterfieldL.H., Journal of Clinical Oncology . 2014,第19期

机译：用新诊断的恶性脑干和非勃治脑膜肿瘤溶解的胶质瘤相关抗原肽和多胞聚环丁酸稳定的抗原特异性免疫应答和临床结果促使赖氨酸和羧甲基纤维素稳定
4. Computational modeling of the immune response to tumor antigens: implications for vaccination [C] . Castiglione, F., Toschi, . 2004

机译：对肿瘤抗原免疫反应的计算模型：对疫苗接种的影响
5. Immune Response to Streptococcus pneumoniae Polysaccharide Vaccination and Antigen-Selected B cells in Highly Susceptible Individuals [D] . Leggat, David Jason. 2014

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6. Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas [O] . Ian F. Pollack, Regina I. Jakacki, Lisa H. Butterfield, 2016

机译：儿科复发性低度神经胶质瘤的初步研究中接种神经胶质瘤相关抗原肽和poly-ICLC疫苗后的免疫应答和结果
7. Comparison of Glioma-associated Antigen Peptide-loaded Versus Autologous Tumor Lysate-loaded Dendritic Cell Vaccination in Malignant Glioma Patients [O] . Robert M. Prins, Xiaoyan Wang, Horacio Soto, 2013

机译：胶质瘤相关抗原肽肽对恶性胶质瘤患者患者的粘性抗原肽肽的与自体肿瘤裂解的树突式细胞疫苗接种疫苗接种

Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas(aEuro)

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