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首页> 外文期刊>Neuro-Oncology >B7-H1 is correlated with malignancy-grade gliomas but is not expressed exclusively on tumor stem-like cells
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B7-H1 is correlated with malignancy-grade gliomas but is not expressed exclusively on tumor stem-like cells

机译：B7-H1与恶性级神经胶质瘤相关，但并非仅在肿瘤干样细胞上表达

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摘要

Human glioblastoma is well known for its capacity to interfere with effective antitumor immune responses. B7-H1 is the third member of the B7 family that plays important roles in tumor immune evasion. Recent studies have shown that brain tumor stem-like cells (TSCs) contribute to tumorigenesis and radioresistance. However, the relationship between B7-H1 and the clinical behavior of brain TSCs remains unclear. In the present study, we report that B7-H1 is correlated with the malignancy grade of astrocyte tumors. B7-H1 was significantly upregulated at the growing edge of the tumors. Immunostaining and flow cytometric analysis indicate that B7-H1 was expressed primarily by Ki67-negative tumor cells. In vitro, tumors cultured under medium favoring the growth of neural stem cells were able to form spheres, along with expression of neural stem/progenitor cell markers. These cells were able to differentiate into different neural lineages when cultured in differentiation medium, indicating that these cells have TSC characteristics. We also found that B7-H1 was expressed, but not exclusively on CD133-positive stem cells. Interestingly, we found that CD133-negative tumor cells also had the capacity to form brain tumors. Our data establish a correlation between the expression of the negative costimulatory molecule B7-H1 and the malignancyrngrade of human gliomas, suggesting that B7-H1 may be a novel tumor marker and target for therapy, although it is not expressed exclusively on brain TSCs.
机译：人胶质母细胞瘤以其干扰有效抗肿瘤免疫反应的能力而闻名。 B7-H1是B7家族的第三个成员，在肿瘤免疫逃逸中起重要作用。最近的研究表明，脑肿瘤干样细胞（TSC）有助于肿瘤发生和放射抵抗。但是，B7-H1与脑TSC的临床行为之间的关系仍不清楚。在本研究中，我们报道B7-H1与星形胶质细胞肿瘤的恶性程度相关。 B7-H1在肿瘤的生长边缘显着上调。免疫染色和流式细胞仪分析表明，B7-H1主要由Ki67阴性肿瘤细胞表达。在体外，在有利于神经干细胞生长的培养基下培养的肿瘤能够与神经干/祖细胞标志物的表达一起形成球体。当在分化培养基中培养时，这些细胞能够分化成不同的神经谱系，表明这些细胞具有TSC特性。我们还发现B7-H1被表达，但不仅仅在CD133阳性干细胞上表达。有趣的是，我们发现CD133阴性肿瘤细胞也具有形成脑瘤的能力。我们的数据建立了负共刺激分子B7-H1的表达与人类神经胶质瘤的恶性程度之间的相关性，这表明B7-H1可能是一种新型的肿瘤标志物和治疗靶标，尽管它并非仅在脑TSCs上表达。

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  • 来源
    《Neuro-Oncology》 |2009年第6期|757-766|共10页
  • 作者

    Yu Yao; Ran Tao; Xiaomei Wang; Yin Wang; Ying Mao; Liang Fu Zhou;

  • 作者单位

    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China;

    Division of Transplant Surgery, Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center Montefiore, Pittsburgh, PA, USA;

    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China;

    Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, China;

    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, 12# Wulumuqi Rd., Shanghai 200040, China;

    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China Department of Neurosurgery, Huashan Hospital, Fudan University, 12# Wulumuqi Rd., Shanghai 200040, China;

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  • 正文语种 eng
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  • 关键词

    B7-H1; brain; gliomas; tumor stem-like cells;

    机译：B7-H1;脑;胶质瘤肿瘤干样细胞;

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