The evolution of stochastic regular motifs for protein sequences

Brian J.Ross

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The evolution of stochastic regular motifs for protein sequences

机译：蛋白质序列随机规则基序的演变

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Stochastic regular motifs are evolved for protein sequences using genetic programming. The motif language, SRE-DNA, is a stochas- tic regular expression language suitable for denoting biosequences. Three restricted versions of SRE-DNA are used as target languages for evolved mo- tifs. The genetic programming experiments are implemented in DCTG-GP, which is a genetic programming system that uses logic-based attribute gram- mars to define the target language for evolved programs. Earlier preliminary work tested SRE-DNA's viablility as a representation language for aligned protein sequences. This work establishes that SRE-DNA is also suitable for evolving motifs for unaligned sets of sequences.

机译：随机规则的基序是使用遗传程序进化为蛋白质序列的。主题语言SRE-DNA是一种适用于表示生物序列的随机正则表达语言。 SRE-DNA的三种受限版本用作进化主题的目标语言。遗传编程实验在DCTG-GP中实现，DCTG-GP是一种遗传编程系统，它使用基于逻辑的属性语法为演化程序定义目标语言。早期的初步工作测试了SRE-DNA的易用性，作为比对蛋白质序列的代表语言。这项工作确定了SRE-DNA也适用于进化未对齐序列集的基序。

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《New Generation Computing》 |2002年第2期|p.187-213|共27页
作者
Brian J.Ross;
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正文语种 eng
中图分类计算技术、计算机技术;
关键词
protein motifs; stochastic regular expressions; grammatical genetic programming; evolutionary computation;

机译：蛋白质基序;随机正则表达式;语法遗传程序设计;进化计算;

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1. RIP to the PIP: PCNA-binding motif no longer considered specific: PIP motifs and other related sequences are not distinct entities and can bind multiple proteins involved in genome maintenance [J] . Boehm Elizabeth M., Washington M. Todd BioEssays : . 2016,第11期

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2. Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. [J] . K Strub, J Moss, P Walter Molecular and Cellular Biology . 1991,第8期

机译：信号识别颗粒（SRP）的9和14个千达尔顿异二聚体蛋白亚基的结合位点仅包含在SRP RNA的Alu域中，并包含在进化过程中保守的序列基序。
3. Expression and characterization of EF-hand I loop mutants of aequorin replaced with other loop sequences of Ca2+-binding proteins: an approach to studying the EF-hand motif of proteins [J] . Inouye Satoshi, Sahara-Miura Yuiko The Journal of Biochemistry . 2016,第1期

机译：水母发光蛋白的EF-手I环突变体的表达和表征，并替换为其他Ca2 +结合蛋白的环序列：研究蛋白EF-手基序的方法
4. The Evaluation of a Stochastic Regular Motif Language for Protein Sequences [C] . Brian J. Ross Genetic and evolutionary computation conference . 2001

机译：对蛋白质序列的随机常规基序语言的评价
5. Motif-based mining of protein sequences. [D] . Liu, Agatha H. 2002

机译：基于主题的蛋白质序列挖掘。
6. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution [O] . Bryan C. Dickinson, Aaron M. Leconte, Benjamin Allen, 2013

机译：使用噬菌体辅助的连续进化对蛋白质进化的路径依赖性和随机性进行实验性询问
7. The Evolution of Stochastic Regular Motifs for Protein Sequences [O] . Brian J. Ross 2002

机译：蛋白质序列随机正则基序的进化

The evolution of stochastic regular motifs for protein sequences

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