Disrupting cancer's production line

ANDY COGHLAN

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Disrupting cancer's production line

机译：破坏癌症的生产线

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If it happened in a factory, it would be condemned as industrial sabotage. But in the battle against cancer, a molecule that wreaks havoc on the protein assembly line is just what is needed. Now a drug that does this is showing early promise, extending one skin cancer patient's life by four years after other treatments had failed. The drug, known as 17 AAG, renders several key signalling proteins useless. Because cancer cells are actively growing and dividing all the time, the ability to manufacture these proteins is much more important than for normal cells.

机译：如果发生在工厂中，将被视为工业破坏活动。但是在抗癌斗争中，正是需要在蛋白质装配线上造成严重破坏的分子。现在，一种能够做到这一点的药物显示出早期的希望，将其他治疗失败后的皮肤癌患者的寿命延长四年。这种被称为17 AAG的药物使几种关键的信号蛋白无用。由于癌细胞一直在活跃地生长和分裂，因此制造这些蛋白质的能力比正常细胞重要得多。

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来源
《New scientist》 |2005年第2505期|p.16|共1页
作者
ANDY COGHLAN;
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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Nielsen , E. Disrupting Breast Cancer Narratives: Stories of Rage and Repair , Toronto : University of Toronto Press 2019 . 184?pp $29.96 (cloth) $29.96 (ebk) ISBN 978‐1‐48750437‐3 Nielsen , E. Nielsen Nielsen , E. E. Disrupting Breast Cancer Narratives: Stories of Rage and Repair Disrupting Breast Cancer Narratives: Stories of Rage and Repair , Toronto Toronto : University of Toronto Press University of Toronto Press 2019 2019 . 184?pp $29.96 (cloth) $29.96 (ebk) ISBN 978‐1‐48750437‐3 [J] . Sociology of health & illness . 2020,第4期

机译：尼尔森，E.破坏乳腺癌叙述：多伦多愤怒和修理故事：多伦多大学出版社2019年。 184年4月9日：多伦多大学多伦多大学2019年出版社2019年。 184？PP $ 29.96（布）$ 29.96（ebk）ISBN 978-1-48750437-3
2. Hypervelocity cratering and disruption of the Northwest Africa 4502 carbonaceous chondrite meteorite: Implications for crater production, catastrophic disruption, momentum transfer and dust production on asteroids [J] . Flynn George J., Durda Daniel D., Molesky Mason J., Planetary and space science . 2020,第Auga期

机译：西北非洲4502碳质铜矿陨石的超细兴高采烈的吸收：对火山口生产，灾难性中断，动量转移和粉尘生产对小行星的影响
3. Hypervelocity cratering and disruption of the Northwest Africa 869 ordinary chondrite meteorite: Implications for crater production, catastrophic disruption, momentum transfer and dust production on asteroids [J] . Flynn George J., Durda Daniel D., Patmore Emma B., Planetary and space science . 2018,第DECa期

机译：西北非洲869个普通陨石陨石的超高速陨石坑和破坏：对小行星的陨石坑生产，灾难性破坏，动量传递和粉尘产生的影响
4. Research on closed-loop supply chain buy back contract of anti-disruption when demand and production cost disruptions [C] . Dong Wei, Yu-yan Wang, Zhi-xin Zhang Chinese Control and Decision Conference . 2013

机译：需求和生产成本中断时闭环供应链反中断购回合同研究
5. Activated epidermal growth factor (EGF) receptor in ovarian cancer cells disrupts the function of integrins: Role in cancer cell morphology, adhesion and migration. [D] . Ning, Yan. 2006

机译：卵巢癌细胞中活化的表皮生长因子（EGF）受体破坏了整联蛋白的功能：在癌细胞形态，粘附和迁移中的作用。
6. Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol [O] . Hyocheol Bae, Sunwoo Park, Changwon Yang, 2021

机译：坎贝格尔中卵巢癌中的内质网和ROS生产的破坏
7. Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol [O] . Hyocheol Bae, Sunwoo Park, Changwon Yang, 2021

机译：坎贝格尔中卵巢癌中的内质网和ROS生产的破坏
8. Screening for Small Molecules That Disrupt IAP-Caspases Binding to Activate Caspases and Induce Apoptosis in Breast Cancers [R] . Sun, Y. 2005

机译：筛选破坏Iap-半胱天冬酶结合激活半胱天冬酶并诱导乳腺癌细胞凋亡的小分子

Disrupting cancer's production line

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