This Is Your Brain. Aging

SHARON BEGLEY

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This Is Your Brain. Aging

机译：这是你的大脑。

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Over the years, timothy salthousehas tested more than 8,000 people in his lab at the University of Virginia, assessing their memories, problem-solving skills, and other mental functions to see how the brain fares with age. The results have been predictably dismal: after age 25 or so, it's pretty much all downhill. (No news there: Plato wrote that when a man grows old, he "can no more learn much than he can run much.") But something bothered Salt-house about the results, and on a late spring day in his office at the Russell Sage Foundation on New York's Upper East Side, where he has been a visiting scholar this year, he whips out a graph that captures the paradox.

机译：多年来，蒂莫西·萨特豪斯（Timothy Salthouse）在他位于弗吉尼亚大学的实验室中对8,000多人进行了测试，评估他们的记忆力，解决问题的能力以及其他心理功能，以观察大脑随着年龄的增长如何。结果令人难以置信：在25岁左右以后，这几乎全都是下坡路了。（没有消息：柏拉图写道，当一个人变老时，他“学到的东西不多，只能跑很多东西。”）但是，有些事情困扰着萨尔特·索尔特对结果的担忧，并于春末在他办公室工作。纽约上东区的罗素·塞奇基金会（Russell Sage Foundation）今年曾是该大学的访问学者，他拍了一张图表，捕捉了这一悖论。

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《Newsweek》 |2010年第1期|P.64-6668|共4页
作者
SHARON BEGLEY;
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收录信息美国《化学文摘》(CA);
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正文语种 eng
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1. The effects of aging on dopaminergic neurotransmission: a microPET study of (11C)-raclopride binding in the aged rodent brain. [J] . Hoekzema E, Herance R, Rojas S, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2010,第4期

机译：衰老对多巴胺能神经传递的影响：老年啮齿动物大脑中（11C）-雷氯必利结合的microPET研究。
2. Dissociation of functional status from accrual of CML and RAGE in the aged mouse brain. [J] . Thangthaeng N, Sumien N, Forster MJ Experimental Gerontology . 2008,第12期

机译：功能性状态从老年小鼠大脑中CML和RAGE的累积中分离。
3. Chronic exposure to low-level lead impairs learning ability during aging and energy metabolism in aged rat brain. [J] . Yun S, Lannert H, Hoyer S Archives of Gerontology and Geriatrics: An International Journal Integrating Experimental, Clinical and Social Studies on Ageing . 2000,第3期

机译：长期暴露于低水平的铅会损害衰老过程中的学习能力以及衰老大鼠大脑的能量代谢。
4. EXPRESSION PROFILE OF DNA DAMAGE SIGNALING GENES IN 2 GY PROTON EXPOSED MOUSE BRAIN. [C] . VIRUPAXI GOORNAVAR, SUDHAKAR BALUCHAMY, DAILA S. GRIDLEY, International astronautical congress . 2013

机译：DNA损伤信号转基因基因在2 GY质子暴露的小鼠脑中的表达谱。
5. Structural and Functional Assessment of Gray Matter and White Matter Microstructure in Late Middle-Age: New Insights on Connectivity, Memory Networks, and the Effects of Psychological Stress on the Aging Brain. [D] . Ly, Martina. 2016

机译：中晚期灰色物质和白色物质微观结构的结构和功能评估：连接性，记忆网络以及心理压力对衰老大脑的影响的新见解。
6. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. [O] . H. Funato, M. Yoshimura, T. Yamazaki, 1998

机译：含有淀粉样β蛋白（Abeta）阳性颗粒的星形胶质细胞与老年人脑中Abeta40阳性弥散性斑块有关。
7. The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. [O] . Fluteau, A., Ince, P.G., Minett, T., 2015

机译：转录因子FOXO3a的核保留与DNa损伤反应和星形胶质细胞增加的谷氨酰胺合成酶表达相关，表明在衰老的大脑中具有神经保护作用。

This Is Your Brain. Aging

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