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首页> 外文期刊>Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment >A Monte-Carlo simulation study of detector array design for dedicated breast metabolic imaging systems
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A Monte-Carlo simulation study of detector array design for dedicated breast metabolic imaging systems

机译：专用乳腺代谢成像系统检测器阵列设计的蒙特卡洛模拟研究

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Development of dedicated metabolic breast imaging systems promise to improve the early detection of cancers in women with radio-dense and/or cystic breasts. Our group is constructing an imager based on discrete detector arrays that will acquire multi-angle data to produce tomographic images of the breast. The goal of this investigation was to utilize Monte-Carlo simulations to determine the effect of detector element dimensions on breast lesion detectability. Specifically, the Geant4 Application for Tomography Emission (GATE) software package was used to simulate the performance of the new system. Scanners configured with detector arrays having square elements with widths of 1.5, 2 and 3mm, and thicknesses of 10, 15 and 20mm were tested. An ellipsoid filled with ~(18)F containing four spheres with diameters of 5, 4, 3 and 2 mm also filled with ~(18)F (target-to-background ratio = 8.5:1) was used to simulate a breast with tracer-avid tumors. Images were created with an iterative maximum likelihood expectation maximization (MLEM) image reconstruction algorithm. Lesion detectability was assessed by calculating the peak signal-to-noise ratio for each sphere. Since the GATE software does not model optical effects in the scintillator, a simulation study investigating photon transport in the detector elements using DETECT97 was performed. Results from these studies indicated that narrow (1.5 or 2.0 mm wide) elements 10 or 15mm in length should produce an imager that would detect breast lesions ≤ 3 mm in diameter.
机译：专用代谢性乳腺成像系统的开发有望改善患有放射密集和/或囊性乳房的女性的癌症早期检测。我们的小组正在构建基于离散检测器阵列的成像器，该成像器将获取多角度数据以产生乳房的断层图像。这项研究的目的是利用蒙特卡洛模拟来确定检测器元件尺寸对乳腺病变可检测性的影响。具体来说，用于X线断层摄影的Geant4应用程序（GATE）软件包用于模拟新系统的性能。测试了配置有探测器阵列的扫描仪，探测器阵列的方形元素的宽度为1.5、2和3mm，厚度为10、15和20mm。使用填充有〜（18）F的椭球体（包含四个直径分别为5、4、3和2 mm的球体）以及也填充有〜（18）F（目标与背景之比= 8.5：1）的椭圆体来模拟示踪抗体肿瘤。使用迭代最大似然期望最大化（MLEM）图像重建算法创建图像。通过计算每个球的峰值信噪比来评估病变的可检测性。由于GATE软件无法对闪烁器中的光学效应进行建模，因此进行了使用DETECT97研究探测器元件中光子传输的模拟研究。这些研究的结果表明，长度为10或15mm的窄（1.5或2.0 mm宽）元件应产生可检测直径≤3 mm的乳房病变的成像仪。

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