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首页> 外文期刊>Physics in medicine and biology. >Design study of a high-resolution breast-dedicated PET system built from cadmium zinc telluride detectors.
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Design study of a high-resolution breast-dedicated PET system built from cadmium zinc telluride detectors.

机译：碲化镉锌锌锌碲化镉探测器高分辨率乳房专用宠物系统的设计研究。

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摘要

We studied the performance of a dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation. The proposed system consists of two 4 cm thick 12 x 15 cm(2) area cadmium zinc telluride (CZT) panels with adjustable separation, which can be put in close proximity to the breast and/or axillary nodes. Unique characteristics distinguishing the proposed system from previous efforts in breast-dedicated PET instrumentation are the deployment of CZT detectors with superior spatial and energy resolution, using a cross-strip electrode readout scheme to enable 3D positioning of individual photon interaction coordinates in the CZT, which includes directly measured photon depth-of-interaction (DOI), and arranging the detector slabs edge-on with respect to incoming 511 keV photons for high photon sensitivity. The simulation results show that the proposed CZT dual-panel PET system is able to achieve superior performance in terms of photon sensitivity, noise equivalent count rate, spatial resolution and lesion visualization. The proposed system is expected to achieve approximately 32% photon sensitivity for a point source at the center and a 4 cm panel separation. For a simplified breast phantom adjacent to heart and torso compartments, the peak noise equivalent count (NEC) rate is predicted to be approximately 94.2 kcts s(-1) (breast volume: 720 cm(3) and activity concentration: 3.7 kBq cm(-3)) for a approximately 10% energy window around 511 keV and approximately 8 ns coincidence time window. The system achieves 1 mm intrinsic spatial resolution anywhere between the two panels with a 4 cm panel separation if the detectors have DOI resolution less than 2 mm. For a 3 mm DOI resolution, the system exhibits excellent sphere resolution uniformity (sigma(rms)/mean) < or = 10%) across a 4 cm width FOV. Simulation results indicate that the system exhibits superior hot sphere visualization and is expected to visualize 2 mm diameter spheres with a 5:1 activity concentration ratio within roughly 7 min imaging time. Furthermore, we observe that the degree of spatial resolution degradation along the direction orthogonal to the two panels that is typical of a limited angle tomography configuration is mitigated by having high-resolution DOI capabilities that enable more accurate positioning of oblique response lines.
机译：我们研究了使用Monte Carlo仿真致力于乳腺癌成像的双面板正电子发射断层扫描（PET）相机的性能。所提出的系统由两种4厘米厚的12×15cm（2）区域镉锌碲化物（CZT）面板组成，可调节分离，可以靠近乳房和/或腋窝节点。区分所提出的系统从以前的母乳专用宠物仪器的努力区分所提出的系统是使用交叉条电极读出方案进行高级空间和能量分辨率的CZT探测器的部署，以实现CZT中各个光子相互作用坐标的3D定位，这包括直接测量的光子深度相互作用（DOI），并在用于高光子敏感度的进入的511keV光子上布置检测器板边缘。仿真结果表明，所提出的CZT双面板PET系统能够在光子敏感度，噪声等效计率，空间分辨率和病变可视化方面实现卓越的性能。建议的系统预计在中心的点源和4厘米的面板分离达到大约32％的光子敏感度。对于与心脏和躯干隔室相邻的简化乳房幻影，预测峰值噪声等效计数（NEC）速率约为94.2 KCTS S（-1）（乳房体积：720cm（3）和活性浓度：3.7kbq cm（ -3））对于大约10％的能量窗口，约为511keV和大约8ns巧合时间窗口。如果检测器具有小于2mm的DOI分辨率，则该系统在两个面板之间的任何位置达到1mm内在空间分辨率。对于3毫米的DII分辨率，系统在4cm宽度FOV上表现出优异的球体分辨率均匀性（Sigma（RMS）/平均值）<或= 10％）。仿真结果表明，该系统具有优异的热球可视化，并且预期在大约7分钟的成像时间内可视化2mm直径的球体，其中5：1的活性浓度比。此外，我们观察到，通过具有高分辨率的DOI能力来减轻沿着与有限角度断层扫描配置的两个面板正交的方向的空间分辨率劣化程度，使得能够更准确地定位倾斜响应线。

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