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首页> 外文期刊>Nuclear Instruments & Methods in Physics Research. B, Beam Interactions with Materials and Atoms >Synchrotron soft X-ray microscopy and XRF to image Single-walled carbon nanotubes in epithelial cells
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Synchrotron soft X-ray microscopy and XRF to image Single-walled carbon nanotubes in epithelial cells

机译：同步加速器软X射线显微镜和XRF成像上皮细胞中的单壁碳纳米管

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Carbon nanotubes (CNTs) have been promoted as nanodevices in the biomedicine areas of diagnosis and therapy. In terms of drug delivery, CNTs could be useful in the case of hydrophobic drugs and multiple co-deliveries of therapeutic and imaging molecules. Epithelial cells, being specialized in absorption and secretion, are the first barrier to overcome. At the same time, several frequent tumors are of epithelial origin (cervix, ovarian, liver). Synchrotron-based imaging and spectroscopic techniques are suitable tools to follow the fate of nanodrugs in epithelial cells. We present an example of multi-microscopy approach combining soft X-ray spectromicroscopy at the TwinMic beamline (Elettra Synchrotron, Trieste, Italy) with light and Scanning Electron (SEM) microscopies. In particular, we show that 2-4 h exposure to SWCNTs is not toxic (no viability changes) to a model of cervical epithelial cells, even though it causes temporary perturbation in the membrane and intracellular structures of exposed cells.
机译：在诊断和治疗的生物医学领域，碳纳米管（CNTs）已被推广为纳米装置。就药物递送而言，CNT在疏水性药物以及治疗和成像分子的多个共同递送的情况下可能是有用的。专门用于吸收和分泌的上皮细胞是首先要克服的障碍。同时，几种常见的肿瘤是上皮起源的（子宫颈，卵巢，肝脏）。基于同步加速器的成像和光谱技术是追踪上皮细胞中纳米药物命运的合适工具。我们提供了一个多显微镜方法的示例，该方法将TwinMic光束线（意大利的里雅斯特的Elettra Synchrotron，意大利）的软X射线光谱显微镜与光和扫描电子（SEM）显微镜相结合。特别是，我们显示，暴露于SWCNT的2-4小时对子宫颈上皮细胞模型无毒（无活力变化），即使它会引起暴露细胞的膜和细胞内结构的暂时扰动。

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