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Molecular imaging of the neurodegenerative diseases: State of the art and perspectives

机译:神经退行性疾病的分子成像:最新技术和观点

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A numerous of molecular targets are involved in neurodegenerative diseases such as Alzheimer disease, Parkinson disease or ALS. Large efforts have been done during the last 10 years, to develop radiopharmaceuticals in order to visualize and to quantify these targets. We will present some radiopharmaceuticals already used in human for research or routine. Moreover, we will present the research on the new tracers such as TAU and synuclein aggregates, new neurotransmission parameters, neuroinflammation. Finally, the role played by these markers for diagnosis, disease evolution and treatment follow-up will be discussed. So the aim of this communication is to present the current situation of molecular imaging research in neurodegenerative diseases exploration, and to discuss the potential applications of the molecular imaging to innovative drug development. (C) 2015 Elsevier Masson SAS. All rights reserved.
机译:许多分子靶标涉及神经退行性疾病,例如阿尔茨海默氏病,帕金森氏病或ALS。在过去的十年中,已经做出了巨大的努力来开发放射性药物,以便可视化和量化这些目标。我们将介绍一些已经用于人体研究或常规的放射性药物。此外,我们将介绍新的示踪剂,如TAU和突触核蛋白聚集体,新的神经传递参数,神经炎症的研究。最后,将讨论这些标志物在诊断,疾病演变和治疗随访中的作用。因此,本交流的目的是介绍分子影像学研究在神经退行性疾病探索中的现状,并讨论分子影像学在创新药物开发中的潜在应用。 (C)2015 Elsevier Masson SAS。版权所有。

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