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首页> 外文期刊>Medecine Nucleaire >Optimisation du protocole d'acquisition de la TEP à la fluorocholine dans la détection des lésions parathyroïdiennes
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Optimisation du protocole d'acquisition de la TEP à la fluorocholine dans la détection des lésions parathyroïdiennes

机译：氟氯胺TEP检测甲状旁腺病变检测的优化

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摘要

18F-Fluorocholine (FCH) PET/CT shows very promising potential for detection of hyperfunctioning parathyroid tumors. However, the optimal time to perform imaging after FCH administration has not yet been determined and protocols are highly variable. The aim of this study was to qualitatively and quantitatively compare 5, 10, 15, 20 and 60 min post-injection acquisition times in patients with primary hyperparathyroidism and equivocal traditional imaging. Thirty-one patients were included. Two observers retrospectively analyzed the five protocols. Any focal increase in FCH uptake was localized and graded on a discrete gradation scale between 1 and 5 to assess the likelihood of hyperfunctioning parathyroid tumors. Gold standard was histopathological findings for the 11 operated patients. Regarding quantitative analysis, ratio of SUVmax of parathyroid foci on SUVmean of thyroid background (as signal-to-noise ratio) were compared between protocols. After injection of 2.5 MBq/kg, FCH PET performed 60 min post-injection (2 min) had the best sensitivity and specificity by lesion (92% and 100% respectively and the best signal-to-noise ratio (median of 2). We suggest performing PET scan 60 min after injection, associated with early acquisition so as not to miss a wash-out hyperfunctioning parathyroid tumors. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译：18F-氟氯胺（FCH）PET / CT表示非常有希望的检测甲状旁腺肿瘤的潜水潜力。然而，尚未确定在FCH管理之后执行成像的最佳时间，并且协议是高度可变的。本研究的目的是定性和定量地比较原发性甲状旁腺功能亢进症患者的5,10,15,20和60分钟注射率和等离异性的传统成像。包括三十一名患者。两个观察者回顾性分析了五种协议。 FCH吸收的任何焦点增加都是本地化的，并在1到5之间的离散渐变比例上进行分级，以评估甲状旁腺肿瘤过度障碍的可能性。黄金标准是11例操作患者的组织病理学发现。关于定量分析，在协议之间比较了甲族甲状腺灶对甲状腺背景SUVMEN的比例（作为信噪比）。注射2.5 mbq / kg后，进行60分钟的FCH PET后注射后（2分钟），病变具有最佳的敏感性和特异性（分别为92％和100％，最佳的信噪比（2）的最佳信噪比（2）。我们建议在注射后进行60分钟进行宠物扫描，与早期采集相关，以免错过洗掉的甲状旁腺肿瘤。（c）2019年Elsevier Masson SAS。版权所有。

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  • 来源
    《Medecine Nucleaire》 |2020年第1期|2-11|共10页
  • 作者

    Lalire P.; Morland D.; Dejust S.; Ly S.; Richard C.; Zalzali M.; Moubtakir A.; Messaoud L.; Godard F.; Jallerat P.; Deguelte S.; Delemer B.; Papathanassiou D.;

  • 作者单位

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France|UFR Med Lab Biophys Reims France|Univ Reims CReSTIC Ctr Rech Sci & Technol Informat & Commun EA 3804 Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Hop Univ Robert Debre Serv Endocrinol Diabetol & Nutr Reims France;

    Inst Godinot Unite Thyroide Reims France;

    Inst Godinot Unite Thyroide Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France;

    Hop Univ Robert Debre Serv Chirurg Viscerale & Endocrinienne Reims France;

    Hop Univ Robert Debre Serv Endocrinol Diabetol & Nutr Reims France;

    Inst Godinot Unite Med Nucl 1 Rue Gen Koenig F-51100 Reims France|UFR Med Lab Biophys Reims France|Univ Reims CReSTIC Ctr Rech Sci & Technol Informat & Commun EA 3804 Reims France;

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  • 关键词

    18F-fluorocholine PET/CT; Hyperfunctioning parathyroid tumors; Hyperparathyroidism; Parathyroid adenoma; Acquisition protocol;

    机译：[18F] -fluorocholine PET / CT;甲状旁腺肿瘤超血症;甲状旁腺腺瘤;甲状旁腺腺瘤;收购议定书;

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