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首页> 外文期刊>Optical engineering >Hyperemic responses of the optic nerve head blood flow to chromatic equiluminant flicker are reduced by ocular hypertension and early glaucoma
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Hyperemic responses of the optic nerve head blood flow to chromatic equiluminant flicker are reduced by ocular hypertension and early glaucoma

机译：高眼压症和早期青光眼减少了视神经头部血流对色等亮度闪烁的充血反应

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摘要

We evaluated in ocular hypertension (OHT) and early glaucoma (EOAG) patients the optic nerve head (ONH) blood flow response (RF_(onh)) to chromatic equiluminant flicker. This stimulus generates neural activity dominated by the parvo-cellular system. Eleven EOAG, 20 OHT patients, and 8 age-matched control subjects were examined. The blood flow (F_(onh)) at the neuroretinal rim was continuously monitored by laser Doppler flow-metry before, during, and after a 60-s exposure to a 4 Hz, red-green equiluminant flicker stimulus (30 deg field). RF_(onh) was expressed as percentage F_(onh)-change during the last 20 s of flicker relative to baseline F_(onh). Responses were collected at a number of temporal sites. The highest RF_(onh) value was used for subsequent analysis. As compared to controls, both OHT and EOAG patients showed a decrease (p ＜ 0.01) in mean RF_(onh). We conclude that RF_(onh) elicited by chromatic equiluminant flicker is abnormally reduced in OHT and EOAG patients indicating an impairment of the parvo-cellular-mediated vasoactivity. This decrease of vascular response may occur independently of neural activity loss early in the disease process.
机译：我们评估了高眼压症（OHT）和早期青光眼（EOAG）患者的视神经头（ONH）血流响应（RF_（onh））对色等亮度闪烁。这种刺激产生细小细胞系统主导的神经活动。检查了11名EOAG，20名OHT患者和8名年龄匹配的对照受试者。在暴露于4 Hz，红绿色等亮度闪烁刺激（30度视野）之前，之中和之后，通过激光多普勒血流仪连续监测神经视网膜边缘的血流（F_（onh））。 RF_（onh）表示为相对于基准F_（onh）的最后20 s闪烁期间F_（onh）的变化百分比。在许多临时地点收集了答复。最高RF_（onh）值用于后续分析。与对照组相比，OHT和EOAG患者的平均RF_（onh）均降低（p ＜0.01）。我们得出的结论是，在OHT和EOAG患者中，由等色光闪烁引起的RF_（onh）异常减少，表明细小细胞介导的血管活性受损。血管反应的这种降低可能独立于疾病过程早期的神经活动丧失而发生。

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