Dual-mode optical projection tomography microscope using gold nanorods and hematoxylin-stained cancer cells

Qin Miao1* Julia Yu2 J. Richard Rahn2 Michael G. Meyer2 Thomas Neumann2 Alan C. Nelson2 and Eric J. Seibel3

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Dual-mode optical projection tomography microscope using gold nanorods and hematoxylin-stained cancer cells

机译：使用金纳米棒和苏木精染色的癌细胞的双模光学投影层析成像显微镜

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An optical projection tomography microscope (OPTM) can improve axial resolution by viewing a sample from different perspectives. Here, we report a dual-mode OPTM that can generate 3D images of single cancer cells in both absorption mode and polarization mode. Cancer cells were labeled with hematoxylin for absorption imaging and nanorods for polarization imaging. Absorption images can provide morphologic information, and polarization images can provide molecular information. The combination of molecular detection and 3D cytological cell analysis may help with early cancer diagnosis.

机译：光学投影断层摄影显微镜（OPTM）可以通过从不同角度查看样本来提高轴向分辨率。在这里，我们报告了一种双模式OPTM，它可以在吸收模式和极化模式下生成单个癌细胞的3D图像。癌细胞用苏木精标记用于吸收成像，而纳米棒标记用于极化成像。吸收图像可以提供形态信息，而偏振图像可以提供分子信息。分子检测和3D细胞学细胞分析的结合可能有助于早期癌症诊断。

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来源
《Optics Letters》 |2010年第7期|p.1037-1039|共3页
作者
Qin Miao1* Julia Yu2 J. Richard Rahn2 Michael G. Meyer2 Thomas Neumann2 Alan C. Nelson2 and Eric J. Seibel3;
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1Department of Bioengineering, University of Washington, NE Pacific St., Seattle, Washington 98195, USA 2VisionGate Incorporated, Gig Harbor, Washington 98335, USA 3Department of Mechanical Engineering, University of Washington, Stevens Way, Seattle, Washington 98195, USA;

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1. Dual-mode probe based on mesoporous silica coated gold nanorods for targeting cancer cells [J] . Wang Z., Zong S., Yang J., Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices . 2011,第6期

机译：基于介孔二氧化硅涂层的金纳米棒的双模探针靶向癌细胞
2. Gold Nanorod/Fe3O4 Nanoparticle "Nano-Pearl-Necklaces" for Simultaneous Targeting, Dual-Mode Imaging, and Photothermal Ablation of Cancer Cells [J] . Chungang Wang, Jiji Chen, Tom Talavage Angewandte Chemie . 2009,第15期

机译：金纳米棒/ Fe3O4纳米粒子“纳米珍珠项链”用于癌细胞的同时靶向，双模式成像和光热消融
3. Gold Nanorod/Fe3O4 Nanoparticle "Nano-Pearl-Necklaces" for Simultaneous Targeting, Dual-Mode Imaging, and Photothermal Ablation of Cancer Cells [J] . Chungang Wang, Jiji Chen, Tom Talavage Angewandte Chemie . 2009,第15期

机译：金纳米棒/ Fe3O4纳米粒子“纳米珍珠项链”用于癌细胞的同时靶向，双模式成像和光热消融
4. Subcellular localization of gold nanorods in cancerous cells [C] . Sana Mesiya, Austin Doughty, Benqing Zhou, Biophotonics and Immune Responses XIV . 2019

机译：金纳米棒在癌细胞中的亚细胞定位
5. Quantification via inductively-coupled plasma optical emission spectroscopy (ICP-OES) of the cellular internalization and nuclear localization of gold nanoparticles passivated with BSA-SV40 large T NLS conjugates after incubation with human cervical cancer (HeLa) cells. [D] . Ryan, Joseph Anthony. 2009

机译：在与人宫颈癌（HeLa）细胞孵育后，通过电感耦合等离子体发射光谱（ICP-OES）对被BSA-SV40大T NLS共轭物钝化的金纳米颗粒的细胞内在化和核定位进行定量。
6. Motility- autocorrelation- and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures [O] . Amy L. Oldenburg, Raghav K. Chhetri, Jason M. Cooper, -1

机译：动力自相关和偏振敏感的光学相干断层扫描可区分3D组织培养物中的细胞和金纳米棒
7. Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging* [O] . Chen, Li-li, Jiang, Li, Wang, Ya-lun, 2010

机译：多层聚电解质涂层金纳米棒作为癌细胞成像的多功能光学对比剂*

Dual-mode optical projection tomography microscope using gold nanorods and hematoxylin-stained cancer cells

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