Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina

You-Bo Zhao and Xin-Cheng Yao

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Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina

机译：两栖动物视网膜内刺激性生理反应的内在光学成像

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We demonstrated near-infrared light imaging of stimulus-modulated physiological activities in an isolatednfrog retina using transient intrinsic optical responses (TIORs). While low-strength visible-light stimulinevoked TIORs with positive polarity, strengthened stimuli elicited additional negative TIORs. Our experi-nmental study and physiological analysis suggest that the negative TIORs are associated with photoreceptornresponse, and the positive TIORs result primarily from dynamic changes of postphotoreceptor response dur-ning retinal activation. In coordination with the sophisticated design of visible-light stimulation protocols,noptical imaging of TIORs promises an important application for noninvasive assessment of retinal photore-nceptor and inner neurons. © 2008 Optical Society of America

机译：我们演示了使用瞬态内在光学响应（TIOR）在离体的蛙视网膜中刺激调节的生理活动的近红外成像。低强度可见光刺激的TIOR呈正极性，而增强刺激会引起其他TIOR阴性。我们的实验研究和生理分析表明，阴性TIOR与光感受器反应有关，而阳性TIOR主要来自视网膜激活过程中感光后反应的动态变化。与可见光刺激方案的复杂设计相协调，TIOR的夜间成像有望在视网膜光感受器和内部神经元的无创评估中获得重要的应用。 ©2008美国眼镜学会

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《Optics Letters》 |2008年第4期|p.342-344|共3页
作者
You-Bo Zhao and Xin-Cheng Yao;
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Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA* Corresponding author: xcy@uab.edu;

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1. Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina [J] . Zhao YB, Yao XC Optics Letters . 2008,第4期

机译：两栖动物视网膜内刺激性生理反应的内在光学成像
2. In vivo imaging of intrinsic optical signals in chicken retina with functional optical coherence tomography [J] . Alireza Akhlagh Moayed, Sepideh Hariri, Vivian Choh, Optics Letters . 2011,第23期

机译：功能性光学相干断层扫描在鸡视网膜中固有光学信号的体内成像
3. Physiologic origin of intrinsic optical signals in human retina [J] . Pfaeffle Clara, Hillmann Dierck, Spahr Hendrik, Investigative ophthalmology & visual science . 2018,第9期

机译：人视网膜中固有光信号的生理来源
4. Dynamic differential imaging of intrinsic optical responses in the retina [C] . Xin-Cheng Yao, Yang-Guo Li, Lei Liu, Photonic therapeutics and diagnostics VI . 2010

机译：视网膜固有光学反应的动态差分成像
5. Exploring intrinsic biomarkers for optical assessment of outer retina. [D] . Lu, Rongwen. 2014

机译：探索内在生物标志物，用于光学评估外部视网膜。
6. Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas [O] . Qiu-Xiang Zhang, Youwen Zhang, Rong-Wen Lu, -1

机译：野生型和突变型小鼠视网膜的比较本征光信号成像
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Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina

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