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Digital Image Analysis of Choroidal Hypoperfusion in Indocyanine Green Angiography Using a Choroid to Disc Gray-Scale Ratio

机译:脉络膜到椎间盘灰度比例的吲哚菁绿血管造影术中脉络膜血流灌注的数字图像分析

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PurposernTo investigate hypoperfusion of the choroidal circulation in the macula, the brightness of the diffuse fluorescence of indocyanine green (ICG) angiogram (IA) was measured and the ratio of brightness of the macula to that of the disc was used for comparison of choroidal perfusion between different angiograms.rnMethodsrnTen eyes of 10 young volunteers under 30 years of age (17-28 years old, average 24.7 years old), 10 eyes of 10 old volunteers over 60 years old (60-78 years old, average 66.7 years old) and 5 eyes of 5 patients with age-related macular degeneration (AMD) were examined by IA. The angiograms at 4 and 16 seconds after dye filling were used to measure the brightness of diffuse fluorescence at the macula and the disc on ICG angiograms with a 256-grade gray scale using the Topcon IMAGEnet computer system. The ratio (ch/d ratio) of the averaged brightness of the macula to that of the disc was calculated for each angiogram.rnResultsrnThe ch/d ratios of the angiograms 4 seconds after dye filling were 1.41 in the young volunteers, 1.23 in the old volunteers and 0.52 in the AMD patients. The ch/d ratios of the angiograms 16 seconds after dye filling were 0.92 in the young volunteers, 1.02 in the old volunteers and 0.80 in AMD. There were significant differences in the ch/d ratios among the 3 groups 4 seconds after dye filling (p=0.007, Kruskal-Wallis H test,) but there were no significant differences 16 seconds after dye filling (p=0.310).rnConclusionrnThe ch/d ratio is an adjunctive method for detecting choroidal hypoperfusion in IA, and mayrnMiki et alrnbe helpful for objective evaluation of the choroidal circulation in chorioretinal diseases.
机译:目的为了研究黄斑中脉络膜循环的灌注不足,测量吲哚菁绿(ICG)血管造影(IA)弥散荧光的亮度,并使用黄斑与椎间盘的亮度之比来比较两者之间的脉络膜灌注不同的血管造影照片。rn方法方法:10位30岁以下的青年志愿者(17-28岁,平均24.7岁)的10眼,10位60岁以上的老年志愿者(60-78岁,平均66.7岁)的10眼和IA检查了5例年龄相关性黄斑变性(AMD)患者中的5眼。使用Topcon IMAGEnet计算机系统,在256级灰度的ICG血管造影照片上,使用染料填充后4秒和16秒的血管造影照片测量黄斑和椎间盘上的漫射荧光的亮度。计算每个血管造影的黄斑平均亮度与椎间盘的平均亮度之比(ch / d比)。rn结果rn青年志愿者在填充染料后4秒的血管造影图ch / d比为1.41,老年人为1.23。志愿者和AMD患者中的0.52。染满染料后16秒的血管造影ch / d比在年轻志愿者中为0.92,在老年志愿者中为1.02,在AMD中为0.80。染料填充后4秒,三组之间的ch / d比存在显着差异(p = 0.007,Kruskal-Wallis H检验),但染料填充后16秒(ch = 0.310)也无显着差异。 / d比是在IA中检测脉络膜灌注不足的一种辅助方法,mayrnMiki等人有助于客观评估脉络膜视网膜疾病中的脉络膜循环。

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