...
首页> 外文期刊>Personalized Medicine >Innovation in personalized medicine: BiDil® as a case study for integrating clinical and policy developments
【24h】

Innovation in personalized medicine: BiDil® as a case study for integrating clinical and policy developments

机译:个性化医疗创新:BiDil ®作为结合临床和政策发展的案例研究

获取原文
获取原文并翻译 | 示例
           

摘要

BiDil® (hydralazine and isosorbide dinitrate) represents an interesting application of personalized medicine – the first pharmaceutical specifically approved by a regulatory agency, the US FDA, for an indication in a particular population based on race as a surrogate phenotypic marker, without a companion genomic diagnostic directed at measuring drug responsiveness. The focus of this paper is to use BiDil as a case study of a personalized medicine application and evaluate its clinical and policy-relevant characteristics as an illustrative example of the usefulness of the Evaluation Data for Assessing Personalized Medicine Translation (EDAPT) evidence base.
机译:BiDil ®(肼苯哒嗪和硝酸异山梨酯)代表了个性化医学的一项有趣应用-第一种经监管机构美国FDA特别批准的药物,可根据种族作为特定人群在特定人群中的适应症表型标记,没有针对测量药物反应性的伴随基因组诊断。本文的重点是将BiDil用作个性化药物应用的案例研究,并评估其临床和政策相关特征,作为评估数据对评估个性化药物翻译(EDAPT)证据基础的有用性的示例。

著录项

  • 来源
    《Personalized Medicine》 |2006年第4期|421-427|共7页
  • 作者单位

    The Methodist Hospital and University of Houston, Program in Personalized Medicine & Targeted Therapeutics and the Abramson Center for the Future of Health, 300 Technology Building, T2–309, Houston, TX 77204–4021, USA.;

    The Methodist Hospital and University of Houston, Program in Personalized Medicine & Targeted Therapeutics and the Abramson Center for the Future of Health, 300 Technology Building, T2–309, Houston, TX 77204–4021, USA.;

    The Methodist Hospital and University of Houston, Program in Personalized Medicine & Targeted Therapeutics and the Abramson Center for the Future of Health, 300 Technology Building, T2–309, Houston, TX 77204–4021, USA.;

    University of California, Department of Clinical Pharmacy, School of Pharmacy, San Francisco, 521 Parnassus Avenue, C-152 Box 0622, University of California, San Francisco, CA 94143–0622, USA;

    University of California, Department of Clinical Pharmacy, School of Pharmacy, San Francisco, 521 Parnassus Avenue, C-152 Box 0622, University of California, San Francisco, CA 94143–0622, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    BiDil®; genotype; health policy; heart failure; hydralazine hydrochloride; isosorbide dinitrate; personalized medicine; pharmacogenomics; phenotypic; race;

    机译:BiDil®;基因型;卫生政策;心脏衰竭;盐酸肼苯哒嗪;硝酸异山梨酯个性化医学;药物基因组学表型种族;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号