Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

Steven A. Jacobs; Sheng-Jiun Wu; Yiqing Feng; Deidra Bethea; Karyn T. O’Neil

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Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

机译：交叉相互作用色谱法：一种识别高度可溶性单克隆抗体候选物的快速方法

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Purpose To develop a high-throughput cross-interaction chromatography screening method to rapidly identify antibody candidates with poor solubility using microgram quantities of purified material.

机译：目的开发一种高通量交叉相互作用色谱筛选方法，以使用微克量的纯化材料快速鉴定溶解性差的候选抗体。

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《Pharmaceutical Research》 |2010年第1期|p.65-71|共7页
作者
Steven A. Jacobs; Sheng-Jiun Wu; Yiqing Feng; Deidra Bethea; Karyn T. O’Neil;
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1. Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates. [J] . Jacobs SA, Wu SJ, Feng Y, Pharmaceutical research . 2010,第1期

机译：交叉相互作用色谱法：一种鉴定高可溶性单克隆抗体候选物的快速方法。
2. Cross-interaction chromatography as a rapid screening technique to identify the stability of new antibody therapeutics [J] . Sarah H.M. Hedberg, Jonathan Rapley, Jonathan M. Haigh, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2018,第期

机译：交叉相互作用色谱作为一种快速筛选技术，以确定新抗体治疗剂的稳定性
3. Rational methods for predicting human monoclonal antibodies retention in protein A affinity chromatography and cation exchange chromatography - Structure-based chromatography design for monoclonal antibodies [J] . Ishihara T, Kadoya T, Yoshida H, Journal of chromatography, A: Including electrophoresis and other separation methods . 2005,第1a2期

机译：预测人单克隆抗体在蛋白A亲和色谱和阳离子交换色谱中保留的合理方法-基于结构的单克隆抗体色谱设计
4. INCREASING VARIANTS IN HYDROPHOBIC INTERACTION CHROMATOGRAPHY DURING STABILITY STUDY OF HUMANISED MONOCLONAL ANTIBODY IDENTIFIED BY LC-MS ESI Q-TOF TOP DOWN, MIDDLE DOWN AND BOTTOM UP ANALYSES [C] . Martin Pauers, Katharina List, Dorothee Wetzel International Mass Spectrometry Conference . 2018

机译：在将LC-MS ESI Q-TOF上下，中下和底部分析中鉴定的人源化单克隆抗体的稳定性研究期间疏水相互作用色谱中的变体。
5. Characterization, Stabilization and Formulation Design of IgG and Secretory IgA Monoclonal Antibody Candidates during Storage and Administration [D] . Hu, Yue. 2019

机译：IgG和分泌IgA单克隆抗体寄生期间IgG和分泌IgA单克隆抗体候选的表征，稳定性和制剂设计
6. Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies [O] . Hongwei Xie, Asish Chakraborty, Joomi Ahn, 2010

机译：使用先进的液相色谱和质谱技术快速比较候选生物仿制药与创新单克隆抗体
7. Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies [O] . Xie, Hongwei, Chakraborty, Asish, Ahn, Joomi, 2010

机译：使用先进的液相色谱和质谱技术快速比较候选生物仿制药与创新单克隆抗体

Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

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