FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

Susanne Matheus; Wolfgang Friess; Hanns-Christian Mahler

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FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

机译：FTIR和nDSC作为高浓度蛋白质制剂的分析工具

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摘要

The aim of the study is to evaluate Fourier-transform infrared spectroscopy (FTIR) as an analytical tool for high-concentrated protein formulations.

机译：这项研究的目的是评估傅立叶变换红外光谱（FTIR）作为高浓度蛋白质制剂的分析工具。

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来源
《Pharmaceutical Research》 |2006年第6期|1350-1363|共14页
作者
Susanne Matheus; Wolfgang Friess; Hanns-Christian Mahler;
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作者单位

Merck KGaA Global Pharmaceutical Development Darmstadt Germany;

Department of Pharmacy Pharmaceutical Technology and Biopharmaceutics Ludwig-Maximilians-University Munich Munich Germany;

Merck KGaA Global Pharmaceutical Development Darmstadt Germany;

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原文格式 PDF
正文语种 eng
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关键词
DSC; formulation development; FTIR; high-concentration protein formulation; melting temperature;

机译：DSC;配方开发;FTIR;高浓度蛋白质配方;熔融温度;

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1. FTIR and nDSC as analytical tools for high-concentration protein formulations. [J] . Matheus S, Friess W, Mahler HC Pharmaceutical research . 2006,第6期

机译：FTIR和nDSC作为高浓度蛋白质制剂的分析工具。
2. A Critical Evaluation of T m(FTIR) Measurements of High-Concentration IgG1 Antibody Formulations as a Formulation Development Tool [J] . Susanne Matheus, Hanns-Christian Mahler, Wolfgang Friess Pharmaceutical Research . 2006,第7期

机译：作为制剂开发工具的高浓度IgG1 抗体制剂T m（FTIR）测量的严格评估
3. A critical evaluation of Tm(FTIR) measurements of high-concentration IgG1 antibody formulations as a formulation development tool. [J] . Matheus S, Mahler HC, Friess W Pharmaceutical research . 2006,第7期

机译：对高浓度IgG1抗体制剂的Tm（FTIR）测量的关键评估，作为制剂开发工具。
4. ANALYTICAL ULTRACENTRIFUGATION: A VALUABLE TOOL TO RECOGNIZE CRYSTALLIZATION CONDITIONS OF PROTEINS [C] . Joachim Behlke, Otto Ristau International workshop on materials processing at high gravity . 2001

机译：分析超速离心：识别蛋白质结晶条件的有价值的工具
5. Comparisons of Two Different Analytical Methodologies for the Characterization of Sub-Visible Particles in Therapeutic Protein Formulations. [D] . Frommknecht, Tobias. 2011

机译：两种不同的分析方法在治疗性蛋白质制剂中表征亚可见颗粒的比较。
6. Bottom-Up Mass Spectrometry–Based Proteomics as an Investigative Analytical Tool for Discovery and Quantification of Proteins in Biological Samples [O] . Ravi Amunugama, Richard Jones, Michael Ford, -1

机译：基于自下而上质谱的蛋白质组学作为发现和定量生物样品中蛋白质的调查分析工具
7. ATR-FTIR: A "rejuvenated" tool to investigate amyloid proteins. [O] . Sarroukh, Rabia, Goormaghtigh, Erik, Ruysschaert, Jean Marie, 2013

机译：ATR-FTIR：研究淀粉样蛋白的“复兴”工具。
8. Network for the Detection of Stratospheric Change (NDSC) FTIR Intercomparison at Table Mountain Facility, November 1996 [R] . Toon, G., Goldman, A., Walsh, C., 2000

机译：1996年11月在桌山设施进行平流层变化检测网（NDsC）FTIR比对

FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

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