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首页> 外文期刊>Pharmacogenomics >Cytochrome P450 loss-of-function polymorphism genotyping on the Agilent Bioanalyzer and clinical application
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Cytochrome P450 loss-of-function polymorphism genotyping on the Agilent Bioanalyzer and clinical application

机译：Agilent Bioanalyzer上的细胞色素P450功能丧失多态性基因分型和临床应用

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摘要

Responses to toxins and drugs, even to standard medical drug treatment regimens, can vary significantly between individuals. Similar dosages can have divergent results due to polymorphisms in the genes that code for the enzymes responsible for the metabolism of drugs. The focus of this report is to describe our exploration of the personalized medicine approach for patient care at Sydney West Area Health Service. We would like to demonstrate the importance of this approach as it is the subject of debate in the medical and scientific community. The critical points in this debate are the cost of testing, laboratory space required and clinical application. We have shown that a simple approach and instruments like the Agilent Bioanalyzer could be cost effective for laboratory operation. The Agilent Bioanalyzer (Agilent Technologies, CA, USA) can be used for proteins, DNA and cell studies. Hence, reduced cost of instruments, laboratory space requirements, maintenance and operational costs are great advantages of this technology, especially for development and research laboratories.
机译：个体之间对毒素和药物的反应，甚至对标准药物治疗方案的反应也可能差异很大。由于编码负责药物代谢的酶的基因中的多态性，相似的剂量可能会有不同的结果。本报告的重点是描述我们对悉尼西区医疗服务中心针对患者护理的个性化医疗方法的探索。我们想证明这种方法的重要性，因为它是医学和科学界争论的主题。这场辩论的关键点是测试成本，所需的实验室空间和临床应用。我们已经证明，简单的方法和仪器（如安捷伦生物分析仪）对于实验室操作而言可能具有成本效益。安捷伦生物分析仪（美国加利福尼亚州安捷伦科技公司）可用于蛋白质，DNA和细胞研究。因此，降低仪器成本，实验室空间需求，维护和运行成本是该技术的巨大优势，特别是对于开发和研究实验室而言。

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