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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Antimicrobial photodynamic therapy as an adjunct for treatment of deep carious lesions-A systematic review
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Antimicrobial photodynamic therapy as an adjunct for treatment of deep carious lesions-A systematic review

机译：抗菌光动力疗法作为治疗深部龋的辅助手段-系统评价

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For deep carious lesions, a more conservative treatment modality ("selective caries removal") has been proposed, where only the heavily contaminated dentine is removed. In this regard, effective adjuncts for cavity disinfection such as the antimicrobial photodynamic therapy (aPDT) can be valuable clinically prior to definitive restoration. Therefore, the aim of this study was to systematically assess clinical studies on the effectiveness of aPDT as a supplementary tool in the treatment of deep caries lesions. Searches were performed in four databases (PubMed, EMBASE, ISI Web of Science, ClinicalTrials.gov) from 1st January, 2011 until 21st June, 2016 for search terms relevant to the observed parameters, pathological condition, intervention and anatomic entity. The pooled information was evaluated according to PRISMA guidelines. At first, 1651 articles were recovered, of which 1249 full-text articles were evaluated, 270 articles thereof were reviewed for eligibility and finally 6 articles met all inclusion criteria. The aPDT protocols involved Methylene Blue, Toluidine Blue and aluminium-chloride-phthalocyanine as photosensitizers and diode lasers, light-emitting diodes and halogen light-sources. The data from five reports, utilizing both culture-dependent and -independent methods, disclosed significant reduction of cariogenic bacterial load after mechanical caries removal with adjunct aPDT. As these studies exhibit some methodological limitations, e.g. lack of positive controls, this systematic review can support the application of aPDT to a limited extent only in terms of reducing the microbial load in deep carious lesions before restorative treatment. (C) 2017 Elsevier B.V. All rights reserved.
机译：对于深龋病灶，已经提出了更保守的治疗方式（“选择性龋齿清除”），其中仅清除了严重污染的牙本质。在这方面，在最终恢复之前，有效的腔体消毒辅助剂（例如抗微生物光动力疗法（aPDT））在临床上可能很有价值。因此，本研究的目的是系统评估aPDT作为治疗深龋病变的辅助工具的有效性的临床研究。从2011年1月1日至2016年6月21日，在四个数据库（PubMed，EMBASE，ISI Web of Science，ClinicalTrials.gov）中进行搜索，以查找与观察到的参数，病理状况，干预和解剖实体相关的搜索词。汇总的信息根据PRISMA指南进行了评估。首先，检索到1651篇文章，其中1249篇全文文章经过了评估，其中270篇文章经过了资格审查，最后有6篇文章符合所有纳入标准。 aPDT协议涉及亚甲基蓝，甲苯胺蓝和氯化铝-酞菁作为光敏剂和二极管激光器，发光二极管和卤素光源。来自五份报告的数据，利用依赖于培养物的方法和依赖于培养物的方法，揭示了用辅助aPDT去除机械龋齿后显着降低了致龋细菌的负荷。由于这些研究显示出一些方法上的局限性，例如由于缺乏阳性对照，这项系统评价仅在减少深度龋齿病变修复前的微生物负荷方面可以支持aPDT的应用。 （C）2017 Elsevier B.V.保留所有权利。

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