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Chlorin e6 conjugated copper sulfide nanoparticles for photodynamic combined photothermal therapy

机译：氯霉素e6共轭硫化铜纳米粒子用于光动力联合光热疗法

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摘要

The photo-based therapeutic approaches have attracted tremendous attention in recent years especially in treatment and management of tumors. Photodynamic and photothermal are two major therapeutic modalities which are being applied in clinical therapy. The development of nanomaterials for photodynamic combined with photothermal therapy has gained significant attention for its treatment efficacy. In the present study, we designed chlorin e6 (Ce6) conjugated copper sulfide (CuS) nanoparticles (CuS-Ce6 NPs) through amine functionalization and the synthesized nanoparticles act as a dual-model agent for photodynamic therapy and photo thermal therapy. CuS-Ce6 NPs showed enhanced photodynamic effect through generation of singlet oxygen upon 670 nm laser illumination. The same nanoparticles exerted thermal response under an 808 nm laser at 2 W/cm(2). The fabricated nanoparlides did nut :low any cytotoxic effect toward breast cancer cells in the absence of light. In vitro cell viability assay showed a potent cytotoxicity in photothermal and photodynamic treatment. Rather than singular treatment, the photodynamic combined photothermal treatment showed an enhanced cytotoxic effect on treated cells. In addition, the CuS-Ce6 NPs exert a photoacoustic signal for non-invasive imaging of treated cells in tissue-mimicking phantom. In conclusion the CuS-Ce6 NPs act as multimodal agent for photo based imaging and therapy.
机译：近年来，基于照片的治疗方法引起了极大的关注，特别是在肿瘤的治疗和治疗中。光动力和光热是在临床治疗中应用的两种主要治疗方式。用于光动力与光热疗法相结合的纳米材料的开发因其治疗功效而受到了广泛的关注。在本研究中，我们通过胺官能化设计了二氢卟酚e6（Ce6）共轭硫化铜（CuS）纳米粒子（CuS-Ce6 NPs），并且合成的纳米粒子充当光动力疗法和光热疗法的双模剂。 CuS-Ce6 NPs通过在670 nm激光照射下产生单线态氧显示出增强的光动力效应。相同的纳米粒子在808 nm激光下以2 W / cm（2）施加热响应。人造纳米微粒确实在没有光照的情况下对乳腺癌细胞没有任何细胞毒性作用。体外细胞生存力测定显示了在光热和光动力治疗中有效的细胞毒性。光动力联合光热处理而不是单一处理，对处理过的细胞显示出增强的细胞毒性作用。另外，CuS-Ce6 NPs发出光声信号，用于组织模拟体模中处理细胞的非侵入性成像。总之，CuS-Ce6 NP充当基于光的成像和治疗的多峰剂。

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