The effect of ALA-PDT under normoxia and cobalt chloride (CoCl2)-induced hypoxia on adhesion molecules (ICAM-1, VCAM-1) secretion by colorectal cancer cells

Kawczyk-Krupka Aleksandra; Czuba Zenon Pawel; Kwiatek Beata; Kwiatek Sebastian; Krupka Magdalena; Sieron Karolina

首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >The effect of ALA-PDT under normoxia and cobalt chloride (CoCl2)-induced hypoxia on adhesion molecules (ICAM-1, VCAM-1) secretion by colorectal cancer cells

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The effect of ALA-PDT under normoxia and cobalt chloride (CoCl2)-induced hypoxia on adhesion molecules (ICAM-1, VCAM-1) secretion by colorectal cancer cells

机译：常氧和氯化钴（CoCl2）诱导的缺氧条件下ALA-PDT对大肠癌细胞分泌黏附分子（ICAM-1，VCAM-1）的影响

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Background: The most fundamental problem in cancer biology research is to understand the mechanisms of cancer cell resistance to oncological therapies. Literature reports emphasize the important role of adhesion molecules: intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 (ICAM-1 and VCAM-1) in cancer progression and resistance to treatment. Photodynamic therapy (PDT) could become the component of a personalized approach to colorectal cancer, therefore we examined the effects of ALA (delta-aminolevulinic) acid PDT in normoxia and under cobalt chloride (CoCl2)-induced hypoxia on ICAM-1 and VCAM-1 secretion by colorectal cancer cells.

机译：背景：癌症生物学研究中最基本的问题是了解癌细胞对肿瘤治疗的抗性机制。文献报道强调粘附分子的重要作用：细胞间粘附分子1和血管细胞粘附分子1（ICAM-1和VCAM-1）在癌症进展和对治疗的抵抗力中。光动力疗法（PDT）可能成为结肠直肠癌个性化治疗方法的组成部分，因此我们研究了ALA（δ-氨基乙酰丙酸）PDT在常氧和氯化钴（CoCl2）诱导的缺氧下对ICAM-1和VCAM-的作用。 1由大肠癌细胞分泌。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2017年第9期|103-115|共13页
作者
Kawczyk-Krupka Aleksandra; Czuba Zenon Pawel; Kwiatek Beata; Kwiatek Sebastian; Krupka Magdalena; Sieron Karolina;
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作者单位

Med Univ Silesia, Ctr Laser Diagnost & Therapy, Dept Internal Dis Angiol & Phys Med, Sch Med,Div Dent Zabrze, Batorego St 15, PL-41902 Bytom, Poland;

Med Univ Silesia, Div Dent Zabrze, Dept Microbiol & Immunol, Sch Med, 19 Jordana St, PL-41808 Zabrze, Poland;

Specialist Hosp 2, Ctr Laser Diagnost & Therapy, Dept Internal Dis Angiol & Phys Med, Batorego St 15, PL-41902 Bytom, Poland;

Specialist Hosp 2, Ctr Laser Diagnost & Therapy, Dept Internal Dis Angiol & Phys Med, Batorego St 15, PL-41902 Bytom, Poland;

Med Univ Silesia, Ctr Laser Diagnost & Therapy, Dept Internal Dis Angiol & Phys Med, Sch Med,Div Dent Zabrze, Batorego St 15, PL-41902 Bytom, Poland;

Med Univ Silesia, Sch Hlth Sci Katowice, Dept Phys Med, Chair Physiotherapy, Medykow St 12, PL-40752 Katowice, Poland;

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正文语种 eng
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关键词
Photodynamic therapy; ICAM-1; VCAM-1; Colorectal cancer; Hypoxia; Cobalt chloride (CoCl2);

机译：光动力疗法;ICAM-1;VCAM-1;大肠癌;缺氧;氯化钴（CoCl2）;

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专利

1. Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer [J] . G Velikova, RE Banks, A Gearing, British Journal of Cancer . 1997,第11期

机译：胃癌患者的循环可溶性粘附分子E-钙黏着蛋白，E-选择蛋白，细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）
2. Synchronous elevation of soluble intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) correlates with gastric cancer progression [J] . Yoo Nae Choon, Chung Hyun Cheol, Chung Hei Cheol, Yonsei Medical Journal . 1998,第1期

机译：可溶性细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）的同步升高与胃癌的进展相关
3. Alterations in intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in human endothelial cells [J] . Habas Khaled, Shang Lijun Tissue and Cell . 2018,第期

机译：在人内皮细胞中的细胞间粘附分子1（ICAM-1）和血管细胞粘附分子1（VCAM-1）的改变
4. Therapeutic Silencing of Hypoxia-Inducible Factor-1α Using Mixed Micelle Particles Inhibits Prostate Cancer Cell Growth under Hypoxia [C] . Xi-Qiu Liu, Meng-Hua Xiong, Jun Wang World biomaterials congress . 2012

机译：混合胶束粒子对缺氧诱导因子-1α的治疗沉默抑制缺氧条件下前列腺癌细胞的生长
5. Expression and regulation of ICAM-1 and VCAM-1 in streptococcal-cell-wall-induced hepatic granuloma [D] . Xie, Lei. 1996

机译：ICAM-1和VCAM-1在链球菌细胞壁诱导的肝肉芽肿中的表达和调控
6. Circulating soluble adhesion molecules E-cadherin E-selectin intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer. [O] . G. Velikova, R. E. Banks, A. Gearing, 1997

机译：胃癌患者的循环可溶性粘附分子E-钙粘着蛋白E-选择蛋白细胞间粘附分子1（ICAM-1）和血管细胞粘附分子1（VCAM-1）。
7. Nickel Chloride and Cobalt Chloride, Two Common Contact Sensitizers, Directly Induce Expression of Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Endothelial Leukocyte Adhesion Molecule (ELAM-1) by Endothelial Cells [O] . Goebeler Matthias, Meinardus-Hager Georg, Roth Johannes, 1993

机译：氯化镍和氯化钴是两种常见的接触增敏剂，它们通过内皮直接诱导细胞间粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞白细胞粘附分子（ELAM-1）的表达细胞

The effect of ALA-PDT under normoxia and cobalt chloride (CoCl2)-induced hypoxia on adhesion molecules (ICAM-1, VCAM-1) secretion by colorectal cancer cells

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