首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Pretreatment of skin using an abrasive skin preparation pad, a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin
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Pretreatment of skin using an abrasive skin preparation pad, a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin

机译:使用研磨性皮肤准备垫,微针设备或离子电渗疗法对皮肤进行预处理可改善离体人体皮肤中氨基乙酰丙酸甲酯的吸收

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摘要

Background: Pretreatment of skin to remove scales/crusts and roughen the surface is essential to enhance the penetration of topically applied methyl aminolevulinate (MAL) prior to photodynamic therapy and to permit daylight to access all parts of the skin lesions. Numerous procedures of skin preparation are currently available. This study compared the in vitro penetration of MAL into ex vivo human skin pretreated with skin preparation pad abrasion or a microneedling device, and evaluated the effectiveness of an iontophoretic device in delivering MAL into ex vivo human skin.
机译:背景:进行皮肤预处理以去除水垢/结皮并使表面变粗糙对于在光动力疗法之前增强局部应用的氨基乙酰丙酸甲酯(MAL)的渗透性并允许日光进入皮肤病变的所有部位至关重要。当前有许多皮肤准备程序。这项研究比较了MAL在经皮肤制备垫磨蚀剂或微针设备预处理的离体人体皮肤中的体外渗透性,并评估了离子电渗疗法设备将MAL递送至离体人类皮肤中的有效性。

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