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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Photodynamic diagnosis of visceral pleural invasion of lung cancer with a combination of 5-aminolevulinic acid and autofluorescence observation systems
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Photodynamic diagnosis of visceral pleural invasion of lung cancer with a combination of 5-aminolevulinic acid and autofluorescence observation systems

机译：结合5-氨基乙酰丙酸和自体荧光观察系统对内脏胸膜浸润的光动力学诊断

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Background: Visceral pleural invasion (PL) is a prognostic factor in lung cancer. In the lung, lymph flows along the pleura, in addition to the flow toward the pulmonary hilum just as the pulmonary arteries and veins run toward it. Even with the same tumor diameter, a PL1 or higher level of pleural invasion is indicative of a more advanced disease stage. Final diagnosis based on the PL level is made by pathological examination of excised specimens. However, if an intraoperative diagnosis can be established, proper selection of the surgical procedure can be made, and unnecessary surgeries for disseminated lesions can be avoided. We investigated optical diagnostic techniques for identifying the presence or absence of visceral pleural invasion in lung cancer by capitalizing on the phenomenon of 5-amino-levulinic acid (5-ALA) being metabolized to a photosensitizing substance or protoporphyrin IX within malignant tumors, generating red luminescence in response to excitation light.
机译：背景：内脏胸膜浸润（PL）是肺癌的预后因素。在肺部，淋巴液沿着胸膜流动，除了流向肺门时，就像肺动脉和静脉朝胸膜流动一样。即使具有相同的肿瘤直径，PL1或更高水平的胸膜浸润也预示着更晚期的疾病阶段。根据PL水平的最终诊断是通过对切除标本进行病理检查来进行的。但是，如果可以确定术中诊断，则可以正确选择手术程序，并且可以避免不必要的扩散病变手术。我们利用5-氨基乙酰丙酸（5-ALA）被代谢为光敏物质或原卟啉IX的现象，利用恶性肿瘤中的现象进行了研究，以鉴定肺癌内脏胸膜浸润的光学诊断技术响应激发光而发光。

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