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Chitosan-based mucoadhesive gel for oral mucosal toluidine blue O delivery: The influence of a non-ionic surfactant

机译:壳聚糖基粘膜粘附凝胶,用于口腔粘膜甲苯胺蓝O的递送:非离子表面活性剂的影响

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摘要

Photodynamic therapy (PDT) has been successfully employed in the treatment of oral cancer. Toluidine blue 0 (TBO) is a photosensitizer (PS) that has exhibited remarkable photocytotoxicity in a variety of tumour cells; however, its physicochemical properties, as well as the physicochemical properties of oral mucosa, prevent the drug from reaching the target site at a therapeutic concentration.
机译:光动力疗法(PDT)已成功地用于治疗口腔癌。甲苯胺蓝0(TBO)是一种光敏剂(PS),在多种肿瘤细胞中均表现出显着的光细胞毒性。然而,其物理化学性质以及口腔粘膜的物理化学性质阻止药物以治疗浓度到达靶位点。

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