• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non small cell lung cancer
【24h】

Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non small cell lung cancer

机译：术前支气管内光动力疗法可改善最初不可手术（无法手术）的局部晚期非小细胞肺癌的可切除性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: This report describes the result of prospective randomized trial to assess effectiveness and safety of neoadjuvant photodynamic therapy (PDT) and chemotherapy as well as possibility for further surgery for locally advanced NSCLC. Methods: Patients with stage IIIA and IIIB central NSCLC (main bronchus/distal trachea involvement) who were not initially eligible for surgery but might be considered as surgery candidates after neoadjuvant therapy were enrolled in the study. They were randomized to either neoadjuvant chemotherapy and endobronchial PDT or chemotherapy alone followed by surgical resection. PDT was done with photosensitizer agent chlorine E6 and 662 nm laser light before each of the three courses of chemotherapy. Results: From January 2008 to December 2011, 42 patients were assigned to PDT arm (n = 21) and No-PDT arm (n = 21). Groups were similar with respect to age, sex, tumor stage, and histology. No PDT major complications were observed. After neoadjuvant treatment partial response revealed in 19 pts (90%) in PDT arm and 16 pts (76%) in No-PDT arm (p = 0.460), these patients underwent thoracotomy. After thoracotomy tumor was unresectable in 3 pts of No-PDT arm (19%). There were 14 pneumonectomies and 5 lobectomies in PDT arm vs. 10 pneumonectomies and 3 lobectomies in No-PDT arm. Completeness of resection was significantly higher in PDT arm (R0-89%, R1-11%)vs. No-PDT arm (R0-54%, R1-46%), p = 0.038. Conclusions: The study demonstrated that neoadjuvant PDT along with chemotherapy is effective, safe and it makes possible to convert to surgery candidates and to improve resection completeness in stage Ⅲ central NSCLC patients.
机译：目的：本报告描述了一项前瞻性随机试验的结果，以评估新辅助光动力疗法（PDT）和化学疗法的有效性和安全性，以及进一步治疗局部晚期NSCLC的可能性。方法：本研究招募了最初不适合手术但可能在新辅助治疗后被视为手术候选者的IIIA和IIIB期中央NSCLC（主要支气管/远端气管受累）患者。他们被随机分为新辅助化疗和支气管内PDT治疗，或者单独接受化学治疗，然后进行手术切除。在三个疗程的每一个疗程之前，均使用光敏剂氯E6和662 nm激光进行PDT。结果：从2008年1月至2011年12月，有42例患者被分为PDT组（n = 21）和No-PDT组（n = 21）。各组在年龄，性别，肿瘤分期和组织学方面相似。没有观察到PDT的重大并发症。在新辅助治疗后，PDT组有19分（90％）出现了局部反应，而No-PDT组有16分（76％）（p = 0.460），这些患者接受了开胸手术。开胸手术后，在3分的No-PDT臂中无法切除肿瘤（19％）。 PDT组有14个肺切除术和5个肺切除术，而No-PDT组有10个肺切除术和3个肺切除术。 PDT组的切除完成率明显更高（R0-89％，R1-11％）。无PDT臂（R0-54％，R1-46％），p = 0.038。结论：该研究表明，新辅助PDT联合化疗是有效，安全的，并且有可能转化为III期中枢NSCLC患者的手术候选者并改善切除的完整性。

著录项

  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2014年第3期|259-264|共6页
  • 作者

    Andrey Akopov; Anatoly Rusanov; Andrey Gerasin; Nikita Kazakov; Margarita Urtenova; Ivan Chistyakov;

  • 作者单位

    Department of Thoracic Surgery, Oncology and Bronchology, Research Institute of Pulmonology, Pavlov' State Medical University, 12 Rentgen St., 197022 Saint-Petersburg, Russia,Department of Surgery #1, First Pavlov State Medical University, Saint-Petersburg, Russia Available online 3 April 2014;

    Department of Surgery #1, First Pavlov State Medical University, Saint-Petersburg, Russia Available online 3 April 2014;

    Department of Surgery #1, First Pavlov State Medical University, Saint-Petersburg, Russia Available online 3 April 2014;

    Department of Surgery #1, First Pavlov State Medical University, Saint-Petersburg, Russia Available online 3 April 2014;

    Department of Thoracic Surgery, Oncology and Bronchology, Research Institute of Pulmonology, First Pavlov State Medical University, Saint-Petersburg, Russia;

    Department of Surgery #1, First Pavlov State Medical University, Saint-Petersburg, Russia Available online 3 April 2014;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Photodynamic therapy; Endobronchial; Neoadjuvant; Chemotherapy; Non-smalt cell lung cancer;

    机译：光动力疗法;支气管内;新辅助剂化学疗法非小细胞肺癌;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号