• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors
【24h】

Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors

机译：卟啉作为5-氨基乙酰丙酸（ALA）给药后膀胱癌的尿生物标志物：光动力筛查肿瘤的潜力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Tumor biomarkers are commonly used for cancer screening and as indicators of treatment effects. We recently reported that urine porphyrin levels from tumor-bearing mice were elevated compared with those from normal mice after administration of 5-aminolevulinic acid (ALA). In the present study, we evaluated the use of urine samples from bladder cancer patients as tumor biomarkers. Methods: ALA, 1.0g, was orally administered to 66 bladder cancer patients and 20 healthy adults. The urine concentrations of uroporphyrin Ⅰ (UPI), uroporphyrin Ⅲ (UPIII), coproporphyrin Ⅰ (CPI), coproporphyrin Ⅲ (CPIII), and total porphyrins were measured using High Performance Liquid Chromatography (HPLC) system. Results: Almost all of the urinary porphyrin concentrations from the patients with bladder cancer were higher than those from healthy adults. Moreover, 8h after ALA administration, urinary UPI and CPI showed high sensitivity (100 for UPI and CPI) and specificity (96.4 for UPI and 91.4 for CPI). Conclusion: These results indicate that the presence of urinary porphyrins after administration of ALA may function as tumor biomarkers. This method represents a possible new tumor screening method called photodynamic screening (PDS) using ALA-induced porphyrins.
机译：背景：肿瘤生物标志物通常用于癌症筛查和治疗效果指标。我们最近报道，服用5-氨基乙酰丙酸（ALA）后，荷瘤小鼠的尿卟啉水平比正常小鼠高。在本研究中，我们评估了膀胱癌患者尿液样本作为肿瘤生物标志物的用途。方法：对66例膀胱癌患者和20例健康成人口服1.0 g ALA。尿液中的尿卟啉Ⅰ（UPI），尿卟啉Ⅲ（UPIII），辅卟啉Ⅰ（CPI），辅卟啉Ⅲ（CPIII）和总卟啉的尿液浓度采用高效液相色谱（HPLC）系统测定。结果：膀胱癌患者的尿卟啉浓度几乎都高于健康成年人。此外，ALA给药后8小时，尿中UPI和CPI表现出较高的敏感性（UPI和CPI为100）和特异性（UPI为96.4，CPI为91.4）。结论：这些结果表明，ALA给药后尿卟啉的存在可能是肿瘤的生物标志物。这种方法代表了一种可能的新肿瘤筛查方法，称为使用ALA诱导的卟啉的光动力学筛查（PDS）。

著录项

  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2013年第4期|484-489|共6页
  • 作者

    Keiji lnoue; Urara Ota; Masahiro lshizuka; Chiaki Kawada; Hideo Fukuhara; Taro Shuin; Ichiro Okura; Tohru Tanaka; Shun-ichiro Ogura;

  • 作者单位

    Department of Urology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan;

    SBI Pharmaceuticals Co., Ltd., Izumi Garden Tower 20F, 1-6-1, Roppongi, Minato-ku, Tokyo 106-6020,Japan;

    SBI Pharmaceuticals Co., Ltd., Izumi Garden Tower 20F, 1-6-1, Roppongi, Minato-ku, Tokyo 106-6020,Japan;

    Department of Urology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan;

    Department of Urology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan;

    Department of Urology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan;

    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B102 Nagatsuta-cho,Midori-ku, Yokohama 226-8501, Japan;

    SBI Pharmaceuticals Co., Ltd., Izumi Garden Tower 20F, 1-6-1, Roppongi, Minato-ku, Tokyo 106-6020,Japan;

    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B102 Nagatsuta-cho,Midori-ku, Yokohama 226-8501, Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    5-Aminolevulinic add; Uroporphyrin; Coproporphyrin; Tumor biomarker; Urine;

    机译：5-氨基乙酰丙酸添加;尿卟啉;卟啉;肿瘤生物标志物;尿;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号