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Fluorescence examination and photodynamic therapy of facial squamous cell carcinoma-A case report

机译：面部鳞状细胞癌的荧光检查和光动力疗法-病例报告

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摘要

Background and objective: To evaluate the usefulness and feasibility of fluorescence examination and photodynamic therapy (PDT) for facial squamous cell carcinoma. Methods: A 68-year-old male patient underwent 3 courses of PDT. The first treatment was carried out using topically applied 5-aminolevulinic acid (ALA) to the affected area (5.0 cm × 2.5 cm) 3 h before light irradiation. ALA/PplX-mediated fluorescence was used to visualize the lesion and its margin. The lesion was illuminated with a 630nm laser at 120J/cm~2. Thirty days later, the residual lesion received the second treatment at the same light dose after topical use of ALA. Despite the tumor was treated with two courses of PDT, The lesion was not cleared completely yet. At last we used topical ALA and intravenous injection of HiPorfin, with the same light dose, then the lesion was cured and the patient was tumor-free followed up for over 15 months. Results: ALA/PplX-mediated fluorescence visualized the lesion location. Complete cure was achieved after the third course of ALA/Hiporfln PDT. During the 15 months of followed up, no recurrence was noticed. Conclusion: ALA assisted fluorescence examination can be a useful tool to visualize the malignant lesion and determine its margin. ALA-PDT is effective for superficial lesions, but for thicker and deeper lesions, systemic administration of photosensitizer is indispensable.
机译：背景与目的：评价荧光检查和光动力疗法（PDT）在面部鳞状细胞癌中的实用性和可行性。方法：一名68岁的男性患者接受了3个疗程的PDT。第一次治疗是在光照前3小时，将5-氨基乙酰丙酸（ALA）局部施用于患处（5.0 cm×2.5 cm）。 ALA / PplX介导的荧光用于可视化病变及其边缘。用630nm的激光以120J / cm〜2照射病灶。 30天后，局部使用ALA后，以相同的光剂量对残留病变进行了第二次治疗。尽管已经用了两个疗程的PDT治疗了肿瘤，但病变尚未完全清除。最后，我们使用局部ALA并以相同的光剂量静脉注射HiPorfin，然后病灶治愈，患者无肿瘤，随访了15个月以上。结果：ALA / PplX介导的荧光可视化了病变部位。在ALA / Hiporfln PDT的第三个疗程后，完全治愈。在随访的15个月中，未发现复发。结论：ALA辅助荧光检查可以作为可视化恶性病变并确定其边缘的有用工具。 ALA-PDT对浅表病变有效，但对于较厚和较深的病变，必须全身性使用光敏剂。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2012年第1期|p.87-90|共4页
  • 作者

    Xiaona Zhang; Jinzhang Chen; Yuling Luo; Lanying Zhang; Rongcheng Luo; Libo Li;

  • 作者单位

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    squamous cell; carcinoma; photodynamic; therapy; fluorescence; diagnosis;

    机译：鳞状细胞癌;光动力治疗;荧光诊断;

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