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Photodynamic therapy in urology: What can we do now and where are we heading?

机译：泌尿外科的光动力疗法：我们现在该怎么办？我们要去哪里？

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摘要

Background: Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitiz- ers. The aim of this study is to review applications of this technique in urology. Materials and methods: We reviewed the literature on PDT for urological malignancies with the following key words: photodynamic therapy, prostate cancer, kidney cancer, urothelial cancer, penile cancer and then by cross-referencing from previously identified studies. Results: Focal therapy of prostate cancer is an application of PDT. Clinical studies are ongoing to determine PDT efficacy and safety. PDT as salvage treatment after radiotherapy has been tested. Oncologic results were promising but important side effects were reported. Individual dosimetric planning is necessary to avoid toxicity. PDT was tested to treat superficial bladder carcinoma with promising oncologic results. Serious side effects have limited use of first photosensitizers generation. Second generation of photosensitizer allowed reducing morbidity. For upper urinary tract carcinoma and urethra, data are limited. Few studies described PDT application in penile oncology for conservative management of carcinoma in situ and premalignant lesions. For renal cancer, PDT was only tested on preclinical model despite of its potential application. No data is available concerning PDT application for testicular cancer.Conclusion: PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects.
机译：背景：光动力疗法（PDT）是肿瘤泌尿外科的一项创新技术。随着新型光敏剂的出现，随着治疗计划和光传输技术的进步，它的应用对于所有类型的癌症越来越显得现实。这项研究的目的是审查该技术在泌尿外科中的应用。材料和方法：我们回顾了有关PDT的泌尿系统恶性肿瘤文献，包括以下关键词：光动力疗法，前列腺癌，肾癌，尿路上皮癌，阴茎癌，然后通过对先前确定的研究进行交叉引用。结果：前列腺癌的局部治疗是PDT的一种应用。目前正在进行临床研究以确定PDT的疗效和安全性。 PDT作为放疗后的抢救治疗方法已经过测试。肿瘤学结果令人鼓舞，但已报道了重要的副作用。必须进行个体剂量规划，以避免毒性。对PDT进行了治疗浅表性膀胱癌的测试，并获得了令人鼓舞的肿瘤学结果。严重的副作用限制了第一代光敏剂的使用。第二代光敏剂可降低发病率。对于上尿路癌和尿道，数据有限。很少有研究描述PDT在阴茎肿瘤学中用于保守治疗癌原位和癌前病变的应用。对于肾癌，尽管PDT具有潜在的用途，但仅在临床前模型上进行了测试。结论：PDT在泌尿外科的临床应用已证明是一种与重要发病率保持平衡的效率。新一代光敏剂的开发和照明方案的改进应可减少副作用。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2012年第3期|p.261-273|共13页
  • 作者

    G. Bozzini MD; P. Colin; N. Betrouni; P. Nevoux; A. Ouzzane; P. Puech; A. Villers; S. Mordon;

  • 作者单位

    Department of Urology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France,Inserm U703, 152 rue du Docteur Yersin, 59120 Loos, France,Universite Lille Nord de France, CHU Lille, F-59000 Lille, France;

    Department of Urology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France,Inserm U703, 152 rue du Docteur Yersin, 59120 Loos, France,Universite Lille Nord de France, CHU Lille, F-59000 Lille, France;

    Inserm U703, 152 rue du Docteur Yersin, 59120 Loos, France,Universite Lille Nord de France, CHU Lille, F-59000 Lille, France;

    Department of Urology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France;

    Department of Urology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France;

    Department of Radiology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France;

    Department of Urology, Centre Hospitalier Regional Universitaire de Lille, avenue oscar lambret, Lille, France;

    Inserm U703, 152 rue du Docteur Yersin, 59120 Loos, France,Universite Lille Nord de France, CHU Lille, F-59000 Lille, France;

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  • 正文语种 eng
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  • 关键词

    photodynamic therapy; prostate cancer; penile cancer; urothelial cancer; kidney cancer; testicular cancer;

    机译：光动力疗法;前列腺癌;阴茎癌尿路上皮癌肾癌睾丸癌;

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